Table 4 Multivariable analysis of clinical and laboratory factors associated with death at 72 h including LC at 8 h post-randomisation

LC criteria^b at 8 h

No

1.00 (Ref.)^c

< 0.001

Yes

0.24 (0.14, 0.42)

Hyperlactataemia on admission (≥ 5 mmol/L)

No

1.00 (Ref.)^c

< 0.001

Yes

6.61 (3.56, 12.30)

FEAST fluid intervention arm

Control

1.00 (Ref.)^c

< 0.01

Fluid bolus

2.48 (1.36, 4.51)

Malaria

No

1.00 (Ref.)^c

0.01

Yes

0.52 (0.31, 0.87)

Severe anaemia

No

1.00 (Ref.)^c

0.05

Yes

0.57 (0.32, 0.99)

Level of consciousness

Alert

1.00 (Ref.)^c

Prostration

0.87 (0.38, 2)

0.78

Coma

4.29 (1.8, 10.24)

0.001

BUN (mmol/L)

< 7.14

1.00 (Ref.)^c

< 0.001

≥ 7.14

3.13 (1.80, 5.43)

Age (months)

≥ 12

1.00 (Ref.)^c

< 0.001

< 12

3.37 (1.95, 5.82)

Gender

Male

1.00 (Ref.)^c

0.66

Female

1.11 (0.69, 1.81)

Site

Mbale

1.00 (Ref.)^c

Kilifi

2.16 (0.82, 5.75)

0.12

Mulago

2.73 (1.29, 5.78)

< 0.01

Soroti

1.31 (0.58, 2.95)

0.52

Lacor

3.12 (1.19, 8.2)

0.02

Teule

2.93 (1.05, 8.22)

0.04