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Table 4 Multivariable analysis of clinical and laboratory factors associated with death at 72 h including LC at 8 h post-randomisation

From: Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa

  Categories Adjusted OR of death (95% CI) p valuea
LC criteriab at 8 h No 1.00 (Ref.)c < 0.001
Yes 0.24 (0.14, 0.42)
Hyperlactataemia on admission (≥ 5 mmol/L) No 1.00 (Ref.)c < 0.001
Yes 6.61 (3.56, 12.30)
FEAST fluid intervention arm Control 1.00 (Ref.)c < 0.01
Fluid bolus 2.48 (1.36, 4.51)
Malaria No 1.00 (Ref.)c 0.01
Yes 0.52 (0.31, 0.87)
Severe anaemia No 1.00 (Ref.)c 0.05
Yes 0.57 (0.32, 0.99)
Level of consciousness Alert 1.00 (Ref.)c  
Prostration 0.87 (0.38, 2) 0.78
Coma 4.29 (1.8, 10.24) 0.001
BUN (mmol/L) < 7.14 1.00 (Ref.)c < 0.001
≥ 7.14 3.13 (1.80, 5.43)
Age (months) ≥ 12 1.00 (Ref.)c < 0.001
< 12 3.37 (1.95, 5.82)
Gender Male 1.00 (Ref.)c 0.66
Female 1.11 (0.69, 1.81)
Site Mbale 1.00 (Ref.)c  
Kilifi 2.16 (0.82, 5.75) 0.12
Mulago 2.73 (1.29, 5.78) < 0.01
Soroti 1.31 (0.58, 2.95) 0.52
Lacor 3.12 (1.19, 8.2) 0.02
Teule 2.93 (1.05, 8.22) 0.04
  1. aWald test p values
  2. bLC defined as a relative lactate decline ≥ 40% and/or lactate normalisation (lactate < 2.5 mmol/L) at 8 h of randomisation
  3. cReference group