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Table 1 Clinical overlap and dissimilarities between dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD)

From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

Overlap Dissimilarities
Rigidity, akinesia
Cognitive impairments
Frontal executive dysfunction
Visual-constructive impairment
Mild language impairment
Mood disturbances (depression, anxiety)
REM sleep behavior disorder (RBD)
Neuroleptic sensitivity
Some cognitive dysfunctions: deficiencies of attention greater, episodic verbal memory tasks lower in DLB
Tremor less frequent in DLB
Motor performance: slower walk and poorer balance in DLB
Hallucinations (visual) more frequent in DLB
Relative timing of dementia and parkinsonism (one year rule)
Onset of dementia earlier in PDD
Orthostatic hypotension more frequent in DLB
Frontal/temporal-associated cognitive subsets more severe in DLB, cognitive decline is faster in DLB/DLB+AD
Delusions, visual hallucinations, and attentional fluctuation more frequent in DLB
Visual hallucinations: spontaneous in DLB; after L-dopa therapy in PDD, but also in drug-naive cases
  1. AD Alzheimer disease