Table 1 Clinical overlap and dissimilarities between dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD)
From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
Overlap | Dissimilarities |
|---|---|
Rigidity, akinesia Cognitive impairments Frontal executive dysfunction Visual-constructive impairment Mild language impairment Mood disturbances (depression, anxiety) REM sleep behavior disorder (RBD) Neuroleptic sensitivity | Some cognitive dysfunctions: deficiencies of attention greater, episodic verbal memory tasks lower in DLB Tremor less frequent in DLB Motor performance: slower walk and poorer balance in DLB Hallucinations (visual) more frequent in DLB Relative timing of dementia and parkinsonism (one year rule) Onset of dementia earlier in PDD Orthostatic hypotension more frequent in DLB Frontal/temporal-associated cognitive subsets more severe in DLB, cognitive decline is faster in DLB/DLB+AD Delusions, visual hallucinations, and attentional fluctuation more frequent in DLB Visual hallucinations: spontaneous in DLB; after L-dopa therapy in PDD, but also in drug-naive cases |