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Table 2 Laboratory findings overlap and dissimilarities between dementia with Lewy bodies (DLB) and Parkinson disease-dementia (PDD)

From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

Overlap Dissimilarities
Decreased DAT binding in putamen
Reduced cardiac MIBG binding
Medial temporal lobe relative preservation
Occipital hypoperfusion
Similar EEG abnormalities
Similar metabolic decrease in cerebral cortex
GBA mutations
Grey matter cortical atrophy more frequent and more severe in DLB
White matter hyperintensities in temporal lobe more severe and more frequent in DLB
Different functional connectivity, corticostriatal disruption:PDD: frontal cortical disruption; DLB: parietal and occipital disruption
Greater amyloid binding in DLB
Tau-PET imaging more severe in DLB
Several genetic differences (APOE ε4, TFAM))
Decreased DAT binding in caudate related to functional impairment in DLB, not in PDD
SN sonography (size, asymmetry)
CSF AD profile more common in DLB
CSF αSyn oligomeres increased in PDD
  1. AD Alzheimer disease, DAT dopamine transporter, MIBG scintigraphy using metaiodobenzylguanidine labeled to Iodine-123 or Iodine-131, SN substantia nigra, CSF cerebrospinal fluid