Table 2 Laboratory findings overlap and dissimilarities between dementia with Lewy bodies (DLB) and Parkinson disease-dementia (PDD)
From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
Overlap | Dissimilarities |
|---|---|
Decreased DAT binding in putamen Reduced cardiac MIBG binding Medial temporal lobe relative preservation Occipital hypoperfusion Similar EEG abnormalities Similar metabolic decrease in cerebral cortex GBA mutations | Grey matter cortical atrophy more frequent and more severe in DLB White matter hyperintensities in temporal lobe more severe and more frequent in DLB Different functional connectivity, corticostriatal disruption:PDD: frontal cortical disruption; DLB: parietal and occipital disruption Greater amyloid binding in DLB Tau-PET imaging more severe in DLB Several genetic differences (APOE ε4, TFAM)) Decreased DAT binding in caudate related to functional impairment in DLB, not in PDD SN sonography (size, asymmetry) CSF AD profile more common in DLB CSF αSyn oligomeres increased in PDD |