Table 4 Morphological overlap and dissimilarities between dementia with Lewy bodies (DLB) and Parkinson disease-dementia (PDD)
From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
Morphological overlap | Morphological dissimilarities |
|---|---|
Variable mixture of cortical and subcortical LB/αSyn pathology and AD-related pathology Similar Braak LB stages (4-6) and neuritic stages (5 or 6) Relationship between pαSyn and tau aggregation to Aβ deposition in frontal and temporal cortex Initial αSyn aggregation in pre-synapses inducing neurodegeneration via interference with axonal transport Postsynaptic protein downregulation | Higher Aβ load in cortex and striatum in DLB Neuritic plaque scores higher in DLB Higher cortical LB load in temporal and parietal cortex in DLB Increased tau loads in cortex and striatum in DLB More frequent and severe αSyn load in hippocampal subareas C2(3) in DLB Minor deviations in lesion pattern in SNc Pedunculopontine cholinergic cell loss in hallucinating PDD, but not in DLB Higher 5-HT1A receptor binding in cerebral cortex in DLB More frequent cerebral microbleeds in DLB |