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Table 4 Morphological overlap and dissimilarities between dementia with Lewy bodies (DLB) and Parkinson disease-dementia (PDD)

From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

Morphological overlap Morphological dissimilarities
Variable mixture of cortical and subcortical LB/αSyn pathology and AD-related pathology
Similar Braak LB stages (4-6) and neuritic stages (5 or 6)
Relationship between pαSyn and tau aggregation to Aβ deposition in frontal and temporal cortex
Initial αSyn aggregation in pre-synapses inducing neurodegeneration via interference with axonal transport
Postsynaptic protein downregulation
Higher Aβ load in cortex and striatum in DLB
Neuritic plaque scores higher in DLB
Higher cortical LB load in temporal and parietal cortex in DLB
Increased tau loads in cortex and striatum in DLB
More frequent and severe αSyn load in hippocampal subareas C2(3) in DLB
Minor deviations in lesion pattern in SNc
Pedunculopontine cholinergic cell loss in hallucinating PDD, but not in DLB
Higher 5-HT1A receptor binding in cerebral cortex in DLB
More frequent cerebral microbleeds in DLB
  1. LB Lewy body, AD Alzheimer disease, SNc substantia nigra pars compacta