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Table 5 Preliminary neuropathological features of dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD)

From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

Type of lesion DLB PDD
LB / αSyn pathology Both subtypes are characteristic by a combination of progressed LB pathology (LB Braak stage 5–6) and AD pathology of variable severity and extent
Aβ load More severe and extended in cortex and striatum Less severe and less extended
Tau load Higher tau load, particularly in medial temporal cortex Comparatively low tau load in cortex and striatum
αSyn load (hippocampus) CA 1/2 more severely involved CA 2/3 more frequently involved
SN neuronal cell loss Preferentially involving dorsolateral substantia nigra pars compacta More severe, preferentially involving medioventral SNc
Pedunculopontine cholinergic cell loss Negative Positive in hallucinating PDD
5-HT1A receptor binding density in cortex Higher Lower
Cortical LB load Higher in temporal & parietal cortex, hippocampus Diffuse or focal
  1. LB Lewy body, AD Alzheimer disease, SN substantia nigra