Table 5 Preliminary neuropathological features of dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD)
From: Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?
Type of lesion | DLB | PDD |
|---|---|---|
LB / αSyn pathology | Both subtypes are characteristic by a combination of progressed LB pathology (LB Braak stage 5–6) and AD pathology of variable severity and extent | |
Aβ load | More severe and extended in cortex and striatum | Less severe and less extended |
Tau load | Higher tau load, particularly in medial temporal cortex | Comparatively low tau load in cortex and striatum |
αSyn load (hippocampus) | CA 1/2 more severely involved | CA 2/3 more frequently involved |
SN neuronal cell loss | Preferentially involving dorsolateral substantia nigra pars compacta | More severe, preferentially involving medioventral SNc |
Pedunculopontine cholinergic cell loss | Negative | Positive in hallucinating PDD |
5-HT1A receptor binding density in cortex | Higher | Lower |
Cortical LB load | Higher in temporal & parietal cortex, hippocampus | Diffuse or focal |