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Table 7 Absolute risks of falls, fracture, upper gastrointestinal bleed, road traffic accident, adverse drug reaction, and all-cause mortality over 1 year by antidepressant class and for individual antidepressant drugs

From: Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database

 

Absolute risks (per 10,000 persons) over 1 yeara,b

Falls

Fracture

Upper GI bleed

Road traffic accident

Adverse drug reaction

All-cause mortality

Antidepressant class

 SSRIs

57

66

15

49

18

36

 TCAs

47

46

18

38

27

37

 Other antidepressants

52

73

29

53

32

46

 Combined antidepressants

63

67

29

39

46

60

Antidepressant drug

SSRIs:

  Citalopram

56

66

13

50

16

36

  Escitalopram

66

65

19

62

21

38

  Fluoxetine

57

66

17

43

16

35

  Paroxetine

60

71

17

61

26

29

  Sertraline

52

66

5

55

28

38

TCAs:

  Amitriptyline

59

48

19

41

25

49

  Dosulepin

45

52

15

29

22

22

  Lofepramine

30

38

16

39

56

45

  Trazodone

33

34

38

43

c

23

Others:

  Mirtazapine

62

60

19

56

27

59

  Venlafaxine

43

81

42

47

38

34

 All other antidepressants

29

70

23

72

32

52

 No treatment

45

57

12

46

10

33

  1. aAbsolute risks are adjusted for confounders listed in Table 2
  2. bAbsolute risks over 1 year evaluated using adjusted hazard ratios from analyses restricted to 1 year of follow-up
  3. cInsufficient numbers for calculation
  4. SSRIs selective serotonin reuptake inhibitors, TCAs tricyclic and related antidepressants