Absolute risks (per 10,000 persons) over 1 yeara,b | ||||||
---|---|---|---|---|---|---|
Falls | Fracture | Upper GI bleed | Road traffic accident | Adverse drug reaction | All-cause mortality | |
Antidepressant class | ||||||
SSRIs | 57 | 66 | 15 | 49 | 18 | 36 |
TCAs | 47 | 46 | 18 | 38 | 27 | 37 |
Other antidepressants | 52 | 73 | 29 | 53 | 32 | 46 |
Combined antidepressants | 63 | 67 | 29 | 39 | 46 | 60 |
Antidepressant drug | ||||||
SSRIs: | ||||||
Citalopram | 56 | 66 | 13 | 50 | 16 | 36 |
Escitalopram | 66 | 65 | 19 | 62 | 21 | 38 |
Fluoxetine | 57 | 66 | 17 | 43 | 16 | 35 |
Paroxetine | 60 | 71 | 17 | 61 | 26 | 29 |
Sertraline | 52 | 66 | 5 | 55 | 28 | 38 |
TCAs: | ||||||
Amitriptyline | 59 | 48 | 19 | 41 | 25 | 49 |
Dosulepin | 45 | 52 | 15 | 29 | 22 | 22 |
Lofepramine | 30 | 38 | 16 | 39 | 56 | 45 |
Trazodone | 33 | 34 | 38 | 43 | c | 23 |
Others: | ||||||
Mirtazapine | 62 | 60 | 19 | 56 | 27 | 59 |
Venlafaxine | 43 | 81 | 42 | 47 | 38 | 34 |
All other antidepressants | 29 | 70 | 23 | 72 | 32 | 52 |
No treatment | 45 | 57 | 12 | 46 | 10 | 33 |