Skip to main content

Table 7 Absolute risks of falls, fracture, upper gastrointestinal bleed, road traffic accident, adverse drug reaction, and all-cause mortality over 1 year by antidepressant class and for individual antidepressant drugs

From: Antidepressant use and risk of adverse outcomes in people aged 20–64 years: cohort study using a primary care database

  Absolute risks (per 10,000 persons) over 1 yeara,b
Falls Fracture Upper GI bleed Road traffic accident Adverse drug reaction All-cause mortality
Antidepressant class
 SSRIs 57 66 15 49 18 36
 TCAs 47 46 18 38 27 37
 Other antidepressants 52 73 29 53 32 46
 Combined antidepressants 63 67 29 39 46 60
Antidepressant drug
SSRIs:
  Citalopram 56 66 13 50 16 36
  Escitalopram 66 65 19 62 21 38
  Fluoxetine 57 66 17 43 16 35
  Paroxetine 60 71 17 61 26 29
  Sertraline 52 66 5 55 28 38
TCAs:
  Amitriptyline 59 48 19 41 25 49
  Dosulepin 45 52 15 29 22 22
  Lofepramine 30 38 16 39 56 45
  Trazodone 33 34 38 43 c 23
Others:
  Mirtazapine 62 60 19 56 27 59
  Venlafaxine 43 81 42 47 38 34
 All other antidepressants 29 70 23 72 32 52
 No treatment 45 57 12 46 10 33
  1. aAbsolute risks are adjusted for confounders listed in Table 2
  2. bAbsolute risks over 1 year evaluated using adjusted hazard ratios from analyses restricted to 1 year of follow-up
  3. cInsufficient numbers for calculation
  4. SSRIs selective serotonin reuptake inhibitors, TCAs tricyclic and related antidepressants
\