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Table 1 Variant and effect allele with frequencies and magnitude of effect on each atopy-related trait and strength of association with glioma

From: Impact of atopy on risk of glioma: a Mendelian randomisation study

Region SNP Position (bp)a Allelesb MAF Hay fever and asthma Glioma
OR (95% CI) OR (95% CI)
 2q12.1 rs10197862 102,966,549 G/A G = 0.161 1.24 (1.16–1.32) 0.98 (0.93−1.03)
 4p14 rs4833095 38,799,710 C/T T = 0.425 1.20 (1.14–1.26) 1.03 (0.99−1.08)
 5q22.1 rs1837253 110,401,872 T/C T = 0.382 1.17 (1.11–1.23) 0.96 (0.93−1.00)
 8q21.13 rs7009110 81,291,879 C/T C = 0.467 1.14 (1.09–1.19) 0.98 (0.94−1.01)
 9p24.1 rs72699186 6,175,855 A/T T = 0.110 1.26 (1.17–1.36) 0.97 (0.93−1.02)
 11q13.5 rs2155219 76,299,194 G/T G = 0.468 1.17 (1.13–1.21) 1.01 (0.97−1.05)
 15q22.33 rs17294280 67,468,285 A/G G = 0.120 1.18 (1.12–1.25) 0.98 (0.94−1.03)
 16p13.13 rs62026376 11,228,712 T/C T = 0.144 1.17 (1.11–1.23) 0.97 (0.93−1.01)
 17q21.1 rs7212938 38,122,680 T/G G = 0.473 1.16 (1.11–1.22) 1.00 (0.97−1.04)
Region SNP Positiona Allelesb MAF Atopic dermatitis Glioma
OR (95% CI) OR (95% CI)
 1q21.3 rs11205006 152,440,176 T/A A = 0.265 1.62 (1.48–1.77) 0.96 (0.91−1.02)
 1q21.3 rs2228145 154,426,970 A/C C = 0.293 1.15 (1.10–1.20) 0.99 (0.96−1.03)
 2p25.1 rs10199605 8,495,097 A/G A = 0.244 1.04 (1.03–1.06) 1.01 (0.97−1.05)
 2p13.3 rs112111458 71,100,105 G/A G = 0.224 1.08 (1.05–1.10) 0.98 (0.92−1.03)
 2q24.3 rs6720763 167,992,286 T/C C = 0.320 1.29 (1.18–1.41) 1.02 (0.97−1.06)
 5p13.2 rs10214237 35,883,734 C/T C = 0.176 1.06 (1.05–1.08) 0.98 (0.94−1.02)
 5q31.1 rs1295686 131,995,843 C/T T = 0.422 1.35 (1.22–1.49) 0.99 (0.95−1.03)
 6p21.32 rs12153855 32,074,804 T/C C = 0.125 1.58 (1.40–1.78) 0.97 (0.92−1.03)
 8q21.13 rs6473227 81,285,892 A/C A = 0.473 1.06 (1.05–1.08) 0.98 (0.94−1.02)
 9p21.3 rs10738626 22,373,457 C/T C = 0.397 1.23 (1.15–1.32) 0.96 (0.93−1.00)
 10p15.1 rs6602364 6,038,853 G/C G = 0.492 1.05 (1.03–1.07) 1.03 (0.99−1.07)
 11q13.1 rs10791824 65,559,266 A/G G = 0.490 1.15 (1.12–1.19) 0.99 (0.95−1.02)
 11q24.3 rs7127307 128,187,383 C/T C = 0.488 1.09 (1.07–1.11) 0.99 (0.95−1.03)
 11q13.5 rs7130588 76,270,683 G/A G = 0.216 1.29 (1.20–1.38) 1.02 (0.98−1.06)
 14q13.2 rs2143950 35,572,357 C/T T = 0.215 1.08 (1.06–1.10) 1.01 (0.97−1.06)
 16p13.13 rs2041733 11,229,589 C/T T = 0.496 1.09 (1.06–1.11) 0.97 (0.94−1.01)
 19p13.2 rs2164983 8,789,381 C/A A = 0.169 1.16 (1.10–1.22) 0.95 (0.90−1.00)
 20q13.33 rs909341 62,328,742 T/C T = 0.262 1.32 (1.21–1.44) 1.32 (1.26−1.37)
Region SNP Positiona Allelesb MAF IgE levelc Glioma
OR (95% CI) OR (95% CI)
 1q23.2 rs2251746 159,272,060 C/T C = 0.015 1.09 (1.08–1.11) 0.98 (0.95−1.02)
 5q31.1 rs20541 131,995,964 A/G A = 0.270 1.08 (1.06–1.10) 1.01 (0.97−1.06)
 6p22.1 rs2571391 29,923,838 C/A C = 0.303 1.06 (1.05–1.08) 0.97 (0.94−1.01)
 6p21.32 rs2858331 32,681,277 A/G G = 0.490 1.04 (1.03–1.06) 1.02 (0.98−1.06)
 12q13.3 rs1059513 57,489,709 C/T C = 0.070 1.13 (1.09–1.17) 0.97 (0.92−1.03)
Region SNP Positiona Allelesb MAF Self–reported allergy Glioma
OR (95% CI) OR (95% CI)
 2q12.1 rs10189699 102,879,464 A/C A = 0.143 1.16 (1.12–1.20) 0.99 (0.94−1.04)
 2q33.1 rs10497813 198,914,072 T/G T = 0.401 1.08 (1.05–1.11) 0.99 (0.96−1.03)
 3q28 rs9860547 188,128,979 G/A A = 0.272 1.08 (1.05–1.11) 1.02 (0.98−1.06)
 4p14 rs2101521 38,811,551 A/G A = 0.475 1.15 (1.12–1.18) 1.02 (0.98−1.07)
 4q27 rs17388568 123,329,369 G/A A = 0.141 1.08 (1.05–1.11) 1.01 (0.97−1.05)
 5p13.1 rs7720838 40,486,896 G/T T = 0.362 1.08 (1.06–1.11) 1.02 (0.99−1.06)
 5q22.1 rs1438673 110,467,499 T/C C = 0.296 1.12 (1.09–1.15) 0.97 (0.94−1.01)
 6p21.33 rs9266772 31,352,113 T/C C = 0.175 1.11 (1.08–1.14) 1.03 (0.98−1.08)
 9p24.1 rs7032572 6,172,380 A/G G = 0.114 1.12 (1.08–1.16) 0.97 (0.93−1.02)
 10p14 rs962993 9,053,132 T/C T = 0.106 1.07 (1.05–1.10) 1.02 (0.98−1.06)
 11q13.5 rs2155219 76,999,194 G/T G = 0.468 1.11 (1.09–1.14) 1.01 (0.97−1.05)
 15q22.33 rs17228058 67,450,305 A/G G = 0.100 1.08 (1.05–1.11) 1.00 (0.96−1.04)
 17q21.1 rs9303280 38,074,031 T/C T = 0.346 1.07 (1.05–1.09) 0.98 (0.94−1.02)
 20q13.2 rs6021270 50,141,264 C/T T = 0.346 1.16 (1.10–1.22) 1.02 (0.94−1.10)
  1. aNCBI build 37
  2. bReference allele/effect allele
  3. cPer standard deviation
  4. MAF minor allele frequency, OR odds ratio, SNP single nucleotide polymorphism
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