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Table 2 Inverse-variance weighting, maximum likelihood estimation, weighted median estimate, mode-based estimate and Mendelian randomisation-Egger test results for combined atopy-related instrumental variables

From: Impact of atopy on risk of glioma: a Mendelian randomisation study

Trait IVW MLE WME MBE MR-Egger slope MR-Egger intercept
OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P Estimate (95% CI) P
Asthma and hay fever 0.96 (0.90–1.03) 0.248 0.96 (0.93–1.00) 0.066 0.93 (0.86–1.01) 0.087 0.91 (0.80–1.04) 0.191 0.99 (0.72–1.36) 0.951 −0.007 (−0.030 to 0.016) 0.542
Atopic dermatitis 0.96 (0.93–1.00) 0.041 0.96 (0.94–0.99) 0.003 0.96 (0.91–1.01) 0.114 0.97 (0.92–1.02) 0.194 0.97 (0.92–1.03) 0.375 0.004 (−0.014 to 0.006) 0.396
IgE level 0.88 (0.69–1.13) 0.319 0.88 (0.74–1.05) 0.157 0.83 (0.61–1.12) 0.218 0.82 (0.57–1.19) 0.355 0.63 (0.32–1.25) 0.184 0.027 (0.001 to 0.053) 0.042
Self-reported allergy 1.03 (0.95–1.11) 0.534 1.02 (0.97–1.08) 0.429 1.08 (0.97–1.20) 0.184 1.12 (0.92–1.36) 0.275 0.92 (0.69–1.22) 0.540 0.017 (0.003 to 0.031) 0.018
  1. CI confidence interval, IVW inverse-variance weighting, MBE mode-based estimate, MLE maximum likelihood estimation, MR Mendelian randomisation, OR odds ratio, WME weighted median estimate
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