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Table 1 Characteristics of study participants by genotype

From: Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals

  CC TC TT P
Number of individuals (%) 16,076 (15.5) 49,315 (47.4) 38,596 (37.1)  
Age (years) 58 (48–68) 58 (48–67) 58 (48–67) 0.4
Female (%) 55 55 55 0.9
Total cholesterol (mmol/L) 5.6 (4.9–6.4) 5.6 (4.9–6.3) 5.6 (4.9–6.4) 0.1
LDL cholesterol (mmol/L) 3.2 (2.6–3.9) 3.2 (2.6–3.9) 3.2 (2.6–3.9) 0.1
HDL cholesterol (mmol/L) 1.6 (1.2–1.9) 1.6 (1.2–1.9) 1.6 (1.2–1.9) 0.8
Triglycerides (mmol/L) 1.4 (1.0–2.1) 1.4 (1.0–2.1) 1.4 (1.0–2.1) 0.5
Body mass index (kg/m2) 26 (23–28) 26 (23–28) 26 (23–28) 0.3
Hypertension (%) 59 59 60 0.4
Diabetes mellitus (%) 4 4 4 0.3
Smoking (%) 21 21 21 1
Alcohol consumption (%) 17 17 18 0.6
Physical inactivity (%) 54 54 54 0.9
Postmenopausal (%)a 68 67 66 0.4
Hormonal replacement therapy (%)a 11 11 10 0.1
Lipid-lowering therapy (%) 10 11 11 0.02
Education < 8 years (%) 13 12 13 0.4
  1. Values are median (interquartile range) or percentage, and are from the day of enrollment in 2003 and onwards for CGPS and 1991–1994 or 2001–2003 for CCHS. Hypertension was use of anti-hypertensive medication and/or a systolic blood pressure of 140 mmHg or greater, and/or a diastolic blood pressure of 90 mmHg or greater. Diabetes mellitus was self-reported disease, use of insulin, or oral hypoglycemic agents, and/or non-fasting plasma glucose levels of more than 11 mmol/L (>198 mg/dL). Smoking was current smoking. Alcohol consumption was >14/21 units per week for women/men (1 unit = 12 g alcohol, equivalent to one glass of wine or one beer (33 cL)). Physical inactivity was ≤4 hours per week of light physical activity in leisure time. Women reported menopausal status and use of hormonal replacement therapy. Lipid-lowering therapy was primarily statins (yes/no) and education was < 8 years of education
  2. HDL high-density lipoprotein, LDL low-density lipoprotein
  3. aFor women only