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Table 4 Quality assessment of included case series and case reports

From: Efficacy and safety of methylene blue in the treatment of malaria: a systematic review

Study:

First Author

Place of study

(Year)

Score for studiesa

Total score

What is the overall degree of presentation of study details?

Detailed presentation of study participant characteristics?

Case definition clearly reported?

Clear description of malaria treatment reported?

Clear reporting on the follow-up period?

Appropriate reporting of efficacy outcomes?

Appropriate reporting of safety outcomes?

Case series

 

Mayer

Russia

(1919) [62]

2

0

2

2

2

2

2

12

Panse

Africa

(1902) [63]

2

0

2

2

1

1

0

8

Glogner Indonesia (1901) [64]

2

2

2

2

1

1

0

10

Ollwig

Africa (1899) [65]

2

1

1

2

1

2

2

11

Cardamatis

Greece

(1898) [66]

1

0

1

2

1

1

1

7

Röttger

Germany (1895) [67]

2

2

1

2

1

2

2

12

Ferreira

Brazil

(1893) [68]

2

2

1

2

2

2

2

13

Parenski and Blatteis

Europe (1893) [69]

1

0

1

2

1

1

1

7

Thayer

USA

(1892) [70]

2

2

1

2

1

2

2

12

Guttmann and Ehrlich

Germany

(1891) [29]

2

2

2

2

1

2

2

13

Case reports

 

Mühlens Germany (1921) [71]

1

0

2

2

2

2

0

9

Atkinson

China

(1903) [72]

1

1

1

2

2

2

1

10

Sivers

Germany

(1901)

cited by

Merck

(1922) [73, 74]

1

2

2

2

1

1

2

11

Anonymous

Germany

(1893) [75]

2

2

2

2

2

2

2

14

Trintignan

India

(1882)

cited by

Röttger

(1895) [67]

1

1

1

2

2

2

0

9

  1. aThe items are scored 0 (not reported), 1 (reported but inadequate) or 2 (reported and adequate). The global ideal score was 14 for case series and case reports
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BMC Medicine

ISSN: 1741-7015

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