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Table 4 Quality assessment of included case series and case reports

From: Efficacy and safety of methylene blue in the treatment of malaria: a systematic review

Study:
First Author
Place of study
(Year)
Score for studiesa Total score
What is the overall degree of presentation of study details? Detailed presentation of study participant characteristics? Case definition clearly reported? Clear description of malaria treatment reported? Clear reporting on the follow-up period? Appropriate reporting of efficacy outcomes? Appropriate reporting of safety outcomes?
Case series  
Mayer
Russia
(1919) [62]
2 0 2 2 2 2 2 12
Panse
Africa
(1902) [63]
2 0 2 2 1 1 0 8
Glogner Indonesia (1901) [64] 2 2 2 2 1 1 0 10
Ollwig
Africa (1899) [65]
2 1 1 2 1 2 2 11
Cardamatis
Greece
(1898) [66]
1 0 1 2 1 1 1 7
Röttger
Germany (1895) [67]
2 2 1 2 1 2 2 12
Ferreira
Brazil
(1893) [68]
2 2 1 2 2 2 2 13
Parenski and Blatteis
Europe (1893) [69]
1 0 1 2 1 1 1 7
Thayer
USA
(1892) [70]
2 2 1 2 1 2 2 12
Guttmann and Ehrlich
Germany
(1891) [29]
2 2 2 2 1 2 2 13
Case reports  
Mühlens Germany (1921) [71] 1 0 2 2 2 2 0 9
Atkinson
China
(1903) [72]
1 1 1 2 2 2 1 10
Sivers
Germany
(1901)
cited by
Merck
(1922) [73, 74]
1 2 2 2 1 1 2 11
Anonymous
Germany
(1893) [75]
2 2 2 2 2 2 2 14
Trintignan
India
(1882)
cited by
Röttger
(1895) [67]
1 1 1 2 2 2 0 9
  1. aThe items are scored 0 (not reported), 1 (reported but inadequate) or 2 (reported and adequate). The global ideal score was 14 for case series and case reports