Table 4 Two separate multivariable linear models to test the association of the dependent variable with the type of regimen started after switch. Every model is adjusted for: age, gender, mode of HIV transmission, Italian nationality, previous AIDS event, years of HIV infection, HCV co-infection, HIV RNA and CD4 at cART initiation, CD4 and CD8 count at switch, reason for switch, months of viral suppression
a) Multivariable linear regression with changes at 12 months | |||
Coefficient | 95% CI | p value | |
Dependent variable: CD4/CD8 ratio (log10) change at 12 months | |||
Regimen after switch | |||
Triple | Ref. | ||
Dual | −0.03 | −0.05, −0.0002 | 0.049 |
Mono | −0.007 | −0.04, +0.03 | 0.685 |
Dependent variable: CD8 change at 12 months | |||
Regimen after switch | |||
Triple | Ref. | ||
Dual | +99.2 | +12.1, +186.3 | 0.026 |
Mono | +24.7 | −84.1, +133.5 | 0.656 |
Dependent variable: CD4 change at 12 months | |||
Regimen after switch | |||
Triple | Ref. | ||
Dual | +28.8 | −8.0, +65.6 | 0.125 |
Mono | −4.8 | −50.8, +41.1 | 0.837 |
b) Multivariable linear regression with changes at 24 months | |||
Coefficient | 95% CI | p value | |
Dependent variable: CD4/CD8 ratio (log10) change at 24 months | |||
Regimen after switch | |||
Triple | Ref. | ||
Dual | −0.06 | −0.10, −0.02 | 0.003 |
Mono | −0.01 | −0.06, +0.03 | 0.549 |
Dependent variable: CD8 change at 24 months | |||
Regimen after switch | |||
Triple | Ref. | ||
Dual | +192.0 | −8.4, +392.3 | 0.060 |
Mono | +29.3 | −200.7, +259.4 | 0.802 |
Dependent variable: CD4 change at 24 months | |||
Regimen after switch | |||
Triple | Ref. | ||
Dual | +2.1 | −48.9, +53.1 | 0.936 |
Mono | +51.2 | −7.3, +109.8 | 0.086 |