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Table 4 Two separate multivariable linear models to test the association of the dependent variable with the type of regimen started after switch. Every model is adjusted for: age, gender, mode of HIV transmission, Italian nationality, previous AIDS event, years of HIV infection, HCV co-infection, HIV RNA and CD4 at cART initiation, CD4 and CD8 count at switch, reason for switch, months of viral suppression

From: Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: an observational cohort study

a) Multivariable linear regression with changes at 12 months
  Coefficient 95% CI p value
Dependent variable: CD4/CD8 ratio (log10) change at 12 months
 Regimen after switch
  Triple Ref.   
  Dual −0.03 −0.05, −0.0002 0.049
  Mono −0.007 −0.04, +0.03 0.685
Dependent variable: CD8 change at 12 months
 Regimen after switch
  Triple Ref.   
  Dual +99.2 +12.1, +186.3 0.026
  Mono +24.7 −84.1, +133.5 0.656
Dependent variable: CD4 change at 12 months
 Regimen after switch    
  Triple Ref.   
  Dual +28.8 −8.0, +65.6 0.125
  Mono −4.8 −50.8, +41.1 0.837
b) Multivariable linear regression with changes at 24 months
  Coefficient 95% CI p value
Dependent variable: CD4/CD8 ratio (log10) change at 24 months
 Regimen after switch    
  Triple Ref.   
  Dual −0.06 −0.10, −0.02 0.003
  Mono −0.01 −0.06, +0.03 0.549
Dependent variable: CD8 change at 24 months
 Regimen after switch    
  Triple Ref.   
  Dual +192.0 −8.4, +392.3 0.060
  Mono +29.3 −200.7, +259.4 0.802
Dependent variable: CD4 change at 24 months
 Regimen after switch    
  Triple Ref.   
  Dual +2.1 −48.9, +53.1 0.936
  Mono +51.2 −7.3, +109.8 0.086