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Table 5 Unadjusted and adjusted coefficients from linear mixed model regression analysis to test the association between the dependent variable and type of regimen started after switch. Every model is adjusted for: age, gender, mode of HIV transmission, Italian nationality, previous AIDS event, years of HIV infection, HCV co-infection, HIV RNA and CD4 at cART initiation, CD4 and CD8 count at switch, reason for switch, months of viral suppression

From: Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: an observational cohort study

  Unadjusted coefficient 95% CI Adjusted coefficient 95% CI
CD4/CD8 ratio (log10)
 Regimen after switch
  Triple +0.042 (+0.037, +0.047) +0.056 (+0.047, +0.064)
  Dual −0.013 (−0.029, −0.003) −0.029 (−0.056, −0.002)
  Mono −0.013 (−0.030, +0.005) −0.011 (−0.044, +0.021)
CD8, cells/mm3
 Regimen after switch
  Triple −22.2 (−48.0, +3.7) −25.7 (−51.6, +0.28)
  Dual +114.9 (−32.9, +197.0) +110.4 (+27.3, +193.6)
  Mono +73.5 (−25.4, +172.5) +64.7 (−35.6, +165.0)
CD4, cells/mm3
 Regimen after switch
  Triple +46.7 (+40.3, +53.1) +45.2 (+30.7, +59.6)
  Dual +7.6 (−13.5, +28.8) +32.1 (−13.1, +77.3)
  Mono +23.6 (−1.40, +48.7) +18.0 (−36.9, +72.9)