Table 5 Unadjusted and adjusted coefficients from linear mixed model regression analysis to test the association between the dependent variable and type of regimen started after switch. Every model is adjusted for: age, gender, mode of HIV transmission, Italian nationality, previous AIDS event, years of HIV infection, HCV co-infection, HIV RNA and CD4 at cART initiation, CD4 and CD8 count at switch, reason for switch, months of viral suppression
Unadjusted coefficient | 95% CI | Adjusted coefficient | 95% CI | |
|---|---|---|---|---|
CD4/CD8 ratio (log10) | ||||
Regimen after switch | ||||
Triple | +0.042 | (+0.037, +0.047) | +0.056 | (+0.047, +0.064) |
Dual | −0.013 | (−0.029, −0.003) | −0.029 | (−0.056, −0.002) |
Mono | −0.013 | (−0.030, +0.005) | −0.011 | (−0.044, +0.021) |
CD8, cells/mm3 | ||||
Regimen after switch | ||||
Triple | −22.2 | (−48.0, +3.7) | −25.7 | (−51.6, +0.28) |
Dual | +114.9 | (−32.9, +197.0) | +110.4 | (+27.3, +193.6) |
Mono | +73.5 | (−25.4, +172.5) | +64.7 | (−35.6, +165.0) |
CD4, cells/mm3 | ||||
Regimen after switch | ||||
Triple | +46.7 | (+40.3, +53.1) | +45.2 | (+30.7, +59.6) |
Dual | +7.6 | (−13.5, +28.8) | +32.1 | (−13.1, +77.3) |
Mono | +23.6 | (−1.40, +48.7) | +18.0 | (−36.9, +72.9) |