Parameter | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
---|---|---|---|---|
Clinical AE NOT identified elsewhere in this DAIDS AE grading table | Symptoms causing no or minimal interference with usual social and functional activities | Symptoms causing greater than minimal interference with usual social and functional activities | Symptoms causing inability to perform usual social and functional activities | Symptoms causing inability to perform basic self-care functions OR Medical or operative intervention indicated to prevent permanent impairment, persistent disability, or death |
e.g., Unintentional weight loss | NA | 5–9% loss in body weight from baseline | 10–19% loss in body weight from baseline | ≥ 20% loss in body weight from baseline OR aggressive intervention indicated (e.g., tube feeding or total parenteral nutrition) |