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Table 3 Cross-sectional associations of carotid intima-media thickness and pulse wave velocity with verbal memory test, letter search speed and reaction time at 60–64 years

From: Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

  VMT (n. of words) LSST a (targets) S-RT (s) C-RT (s)
β (95% CI) p β (95% CI) p β (95% CI) p β (95% CI) p
PWV Model 1 −0.355 (−0.616 to −0.095) 0.008 0.004 (−0.018 to 0.026) 0.701 −0.958 (−3.676 to 1.760) 0.489 −1.871 (−5.485 to 1.741) 0.309
Model 2 −0.297 (−0.578 to −0.015) 0.039 0.006 (−0.020 to 0.032) 0.629 −0.344 (−3.402 to 2.714) 0.825 −1.357 (−5.270 to 2.557) 0.496
Model 3 −0.166 (0.461 to 0.129) 0.270 0.007 (−0.022 to 0.036) 0.634 −0.029 (−3.417 to 3.359) 0.987 −1.148 (−5.710 to 2.749) 0.492
cIMT Model 1 0.220 (−3.470 to 3.912) 0.906 −0.036 (−0.218 to 0.145) 0.695 6.819 (−27.267 to 40.906) 0.694 16.606 (−32.294 to 65.507) 0.505
Model 2 0.487 (−3.162 to 4.136) 0.793 −0.049 (−0.235 to 0.138) 0.607 10.673 (−24.072 to 45.418) 0.546 21.282 (−27.069 to 69.635) 0.388
Model 3 1.287 (−2.340 to 4.913) 0.486 −0.015 (−0.222 to 0.192) 0.888 12.470 (−24.800 to 49.740) 0.511 25.184 (−25.895 to 76.264) 0.333
  1. Linear regression models were used to assess associations between variables
  2. cIMT common carotid artery intima-media thickness, PWV pulse wave velocity, VMT verbal memory test, LSST letter search speed test, C-RT choice reaction time test, S-RT simple reaction time test
  3. MODEL 1 adjusted for sex, education and childhood cognition; MODEL 2 = MODEL 1 + adjustments for socioeconomic position at age 53, systolic blood pressure and heart rate at age 60–64; MODEL 3 (fully adjusted) = MODEL 2 + adjustments for total cholesterol, smoking, diabetes and levels of physical activity. In each model, inverse probability weighting was implemented to account for the probability of survival until the end of follow-up
  4. aIndicates log transformed dependent variables
  5. Numbers in italics indicate statistical significance