Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

Table 4 Relationship between cognitive tests at age 60–64 years and residual changes in BMI between three time periods: BMI_36–43 = 36–43 years, BMI_43–53 = 43–53 years, and BMI_{53–60 to 64} = 53–60 to 64 years

	MODEL 1		MODEL 2		MODEL 3
	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
VMT
BMI_36–43	−0.216 (−0.629 to 0.198)	0.306	−0.161 (−0.553 to 0.231)	0.421	−0.199 (−0.632 to 0.234)	0.367
BMI_43–53	0.065 (−0.390 to 0.520)	0.780	0.068 (−0.378 to 0.514)	0.763	0.098 (−0.393 to 0.590)	0.694
BMI_{53–60 to 64}	−0.524 (−0.923 to −0.124)	0.010	−0.515 (−0.915 to −0.115)	0.012	−0.380 (−0.839 to 0.078)	0.104
LSST^a
BMI_36–43	−0.023 (−0.044 to −0.002)	0.029	−0.022 (−0.044 to −0.002)	0.035	−0.024 (−0.047 to −0.002)	0.034
BMI_43–53	−0.012 (−0.033 to 0.010)	0.280	−0.011 (−0.033 to 0.010)	0.305	−0.008 (−0.031 to 0.014)	0.462
BMI_{53–60 to 64}	0.005 (−0.019 to 0.030)	0.680	0.005 (−0.020 to 0.029)	0.704	0.013 (−0.016 to 0.043)	0.367
S-RT
BMI_36–43	2.116 (−1.973 to 6.206)	0.310	2.205 (−1.903 to 6.312)	0.290	3.701 (−0.836 to 8.238)	0.110
BMI_43–53	1.638 (−2.437 to 5.714)	0.430	1.775 (−2.377 to 5.928)	0.402	2.387 (−2.079 to 6.853)	0.294
BMI_{53–60 to 64}	0.698 (−3.119 to 4.514)	0.720	1.142 (−2.672 to 4.955)	0.557	1.859 (−2.514 to 6.233)	0.404
C-RT
BMI_36–43	−1.610 (−7.038 to 3.818)	0.561	−1.433 (−6.968 to 4.101)	0.611	−0.798 (−6.749 to 5.152)	0.792
BMI_43–53	2.581 (−3.305 to 8.468)	0.389	3.145 (−2.879 to 9.170)	0.306	3.021 (−3.570 to 9.612)	0.368
BMI_{53–60 to 64}	2.146 (−3.157 to 7.449)	0.427	2.716 (−2.537 to 7.969)	0.310	4.230 (−1.835 to 10.295)	0.171

Linear regression models were used to assess associations between variables. Significant associations (p < 0.05) are highlighted in bold
^aIndicates log transformed dependent variables. MODEL 1 adjusted for sex, education and childhood cognition; MODEL 2 = MODEL 1 + adjustments for socioeconomic position at age 53, systolic blood pressure and heart rate at age 60–64; MODEL 3 (fully adjusted) = MODEL 2 + adjustments for total cholesterol, smoking, diabetes, diabetes duration and levels of physical activity. In each model, inverse probability weighting was implemented to account for dropout due to death
VMT verbal memory test, LSST letter search speed test, S-RT simple reaction time test, C-RT choice reaction time

ISSN: 1741-7015