Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

Table 5 Relationship between cognitive tests at age 60–64 years and residual changes in waist circumference between three time periods: Waist_36–43 = 36–43 years, Waist_43–53 = 43–53 years, and Waist_{53–60 to 64} = 53–60 to 64 years

	MODEL 1		MODEL 2		MODEL 3
	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P
VMT
WC_36–43	−0.500 (−0.930 to −0.071)	0.022	−0.447 (−0.875, −0.019)	0.041	−0.501 (−0.972 to −0.030)	0.037
WC_43–53	−0.160 (−0.562 to 0.241)	0.434	−0.127 (−0.525 to 0.270)	0.530	−0.090 (−0.511 to 0.330)	0.672
WC_{53–60 to 64}	−0.488 (−0.863 to −0.113)	0.011	−0.444 (−0.822 to −0.067)	0.021	−0.358 (−0.766 to 0.049)	0.085
LSST^a
WC_36–43	−0.026 (−0.051 to −0.002)	0.035	−0.025 (−0.050, −0.001)	0.045	−0.027 (−0.055 to 0.001)	0.058
WC_43–53	−0.001 (−0.026 to 0.024)	0.932	0.0003 (−0.025 to 0.025)	0.983	0.001 (−0.026 to 0.029)	0.916
WC_{53–60 to 64}	0.012 (−0.016 to 0.040)	0.395	0.013 (−0.015 to 0.041)	0.372	0.018 (−0.014 to 0.051)	0.273
S-RT
WC_36–43	4.011 (0.420 to 7.602)	0.029	4.140 (0.473 to 7.806)	0.027	4.435 (0.386 to 8.486)	0.032
WC_43–53	1.604 (−2.445 to 5.654)	0.437	1.718 (−2.408 to 5.844)	0.414	2.466 (−2.002 to 6.936)	0.279
WC_{53–60 to 64}	1.453 (−2.357 to 5.263)	0.454	1.753 (−2.125 to 5.631)	0.375	2.196 (−2.120 to 6.512)	0.318
C-RT
WC_36–43	5.471 (.356 to 10.588)	0.036	0.787 (0.599 to 10.976)	0.029	60.086 (0.389 to 11.783)	0.036
WC_43–53	5.024 (−0.390 to 10.439)	0.069	5.530 (0.095 to 10.965)	0.046	50.251 (−0.752 to 11.254)	0.086
WC_{53–60 to 64}	1.670 (−3.389 to 6.728)	0.517	1.940 (−3.090 to 6.971)	0.449	30.589 (−1.963 to 9.141)	0.205

Linear regression models were used to assess associations between variables
VMT verbal memory test, LSST letter search speed test, C-RT choice reaction time test, S-RT simple reaction time test
Significant associations (p < 0.05) are highlighted in bold
^aIndicates log transformed dependent variables
MODEL 1 adjusted for sex, education and childhood cognition; MODEL 2 = MODEL 1 + adjustments for socioeconomic position at age 53, systolic blood pressure and heart rate at age 60–64; MODEL 3 (fully adjusted) = MODEL 2 + adjustments for total cholesterol, smoking, diabetes, diabetes duration and levels of physical activity. In each model, inverse probability weighting was implemented to account for dropout due to death
Numbers in italics indicate statistical significance

ISSN: 1741-7015