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Table 5 Relationship between cognitive tests at age 60–64 years and residual changes in waist circumference between three time periods: Waist36–43 = 36–43 years, Waist43–53 = 43–53 years, and Waist53–60 to 64 = 53–60 to 64 years

From: Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

  MODEL 1 MODEL 2 MODEL 3
  β (95% CI) P β (95% CI) P β (95% CI) P
VMT       
 WC36–43 −0.500 (−0.930 to −0.071) 0.022 −0.447 (−0.875, −0.019) 0.041 −0.501 (−0.972 to −0.030) 0.037
 WC43–53 −0.160 (−0.562 to 0.241) 0.434 −0.127 (−0.525 to 0.270) 0.530 −0.090 (−0.511 to 0.330) 0.672
 WC53–60 to 64 −0.488 (−0.863 to −0.113) 0.011 −0.444 (−0.822 to −0.067) 0.021 −0.358 (−0.766 to 0.049) 0.085
LSSTa       
 WC36–43 −0.026 (−0.051 to −0.002) 0.035 −0.025 (−0.050, −0.001) 0.045 −0.027 (−0.055 to 0.001) 0.058
 WC43–53 −0.001 (−0.026 to 0.024) 0.932 0.0003 (−0.025 to 0.025) 0.983 0.001 (−0.026 to 0.029) 0.916
 WC53–60 to 64 0.012 (−0.016 to 0.040) 0.395 0.013 (−0.015 to 0.041) 0.372 0.018 (−0.014 to 0.051) 0.273
S-RT       
 WC36–43 4.011 (0.420 to 7.602) 0.029 4.140 (0.473 to 7.806) 0.027 4.435 (0.386 to 8.486) 0.032
 WC43–53 1.604 (−2.445 to 5.654) 0.437 1.718 (−2.408 to 5.844) 0.414 2.466 (−2.002 to 6.936) 0.279
 WC53–60 to 64 1.453 (−2.357 to 5.263) 0.454 1.753 (−2.125 to 5.631) 0.375 2.196 (−2.120 to 6.512) 0.318
C-RT       
 WC36–43 5.471 (.356 to 10.588) 0.036 0.787 (0.599 to 10.976) 0.029 60.086 (0.389 to 11.783) 0.036
 WC43–53 5.024 (−0.390 to 10.439) 0.069 5.530 (0.095 to 10.965) 0.046 50.251 (−0.752 to 11.254) 0.086
 WC53–60 to 64 1.670 (−3.389 to 6.728) 0.517 1.940 (−3.090 to 6.971) 0.449 30.589 (−1.963 to 9.141) 0.205
  1. Linear regression models were used to assess associations between variables
  2. VMT verbal memory test, LSST letter search speed test, C-RT choice reaction time test, S-RT simple reaction time test
  3. Significant associations (p < 0.05) are highlighted in bold
  4. aIndicates log transformed dependent variables
  5. MODEL 1 adjusted for sex, education and childhood cognition; MODEL 2 = MODEL 1 + adjustments for socioeconomic position at age 53, systolic blood pressure and heart rate at age 60–64; MODEL 3 (fully adjusted) = MODEL 2 + adjustments for total cholesterol, smoking, diabetes, diabetes duration and levels of physical activity. In each model, inverse probability weighting was implemented to account for dropout due to death
  6. Numbers in italics indicate statistical significance