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Table 1 Genetic risk burden of birthweight-reducing alleles in diverse populations

From: High burden of birthweight-lowering genetic variants in Africans and Asians

Population N Mean ± s.d. Mean difference (95% CI); P value
All SNPs (n = 59 SNPs)
 AFR 661 64.53 ± 4.21 3.15 (2.64, 3.66); <2 × 10− 16
 AMR 347 64.40 ± 5.33 3.02 (2.34, 3.70); <2 × 10− 16
 EAS 504 64.23 ± 4.34 2.85 (2.29, 3.41); <2 × 10− 16
 SAS 489 62.45 ± 4.59 1.07 (0.49, 1.65); 0.0003
 EUR 503 61.38 ± 4.66 ref
SNPs with ancestral birthweight-reducing alleles (n = 33 SNPs)
 AFR 661 48.85 ± 3.20 7.01 (6.63, 7.39); <2 × 10− 16
 AMR 347 45.58 ± 4.01 3.74 (3.24, 4.24); <2 × 10− 16
 EAS 504 45.07 ± 3.07 3.23 (2.83, 3.63); <2 × 10− 16
 SAS 489 43.86 ± 3.37 2.02 (1.60, 2.44); <2 × 10− 16
 EUR 503 41.84 ± 3.36 ref
SNPs with derived birthweight-reducing alleles (n = 26 SNPs)
 AFR 661 15.68 ± 2.90 −3.85 (−4.20, −3.50); <2 × 10− 16
 AMR 347 18.82 ± 3.16 −0.70 (−1.14, −0.28); 0.0014
 EAS 504 19.16 ± 3.06 −0.37 (−0.76, 0.02); 0.0602
 SAS 489 18.59 ± 3.02 − 0.94 (−1.33, −0.55); 2.1 × 10− 06
 EUR 503 19.53 ± 3.18 ref
  1. AFR Africans, AMR admixed Americans, CI confidence interval, EAS East Asians, EUR Europeans, ref reference, SAS South Asians, s.d. standard deviation, SNP single-nucleotide polymorphism