Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study

Table 2 Characteristics of the single-nucleotide polymorphisms associated with serum magnesium levels

							Association with magnesium^a			Association with CAD^a
SNP	Closest gene	Chr	EA^b	EAF^c	% variance explained	F-statistic	Beta (mmol/L)	SE	P	Beta^d	SE	P
rs4072037	MUC1	1	T	0.54	0.57	136	0.010	0.001	2.0 × 10⁻³⁶	−0.015	0.010	0.11
rs7965584^e	ATP2B1	12	A	0.71	0.25	60	0.007	0.001	1.1 × 10⁻¹⁶	−0.016	0.011	0.13
rs3925584	DCDC5	11	T	0.55	0.25	60	0.006	0.001	5.2 × 10⁻¹⁶	−0.016	0.010	0.09
rs11144134	TRPM6	9	C	0.08	0.23	55	0.011	0.001	8.2 × 10⁻¹⁵	0.039	0.019	0.04
rs13146355	SHROOM3	4	A	0.44	0.19	45	0.005	0.001	6.3 × 10⁻¹³	−0.003	0.010	0.76
rs448378	MDS1	3	A	0.53	0.13	30	0.004	0.001	1.3 × 10⁻⁸	−0.017	0.009	0.06

CAD coronary artery disease, Chr chromosome, EA effect allele, EAF effect allele frequency, SE standard error, SNP single-nucleotide polymorphism
^aBeta coefficients and standard errors were obtained from genome-wide association studies on serum magnesium (23,829 individuals) [22] and CAD (60,801 cases and 123,504 non-cases) [23]
^bAllele associated with higher serum magnesium levels
^cFrequency of the magnesium-raising allele in the magnesium genome-wide association study [22]
^dLog odds ratio of CAD for each additional magnesium-increasing allele
^eProxy (rs10858938; r² = 0.96 in European descent individuals) was used in the CAD data

ISSN: 1741-7015