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Table 2 Characteristics of the single-nucleotide polymorphisms associated with serum magnesium levels

From: Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study

        Association with magnesiuma Association with CADa
SNP Closest gene Chr EAb EAFc % variance explained F-statistic Beta (mmol/L) SE P Betad SE P
rs4072037 MUC1 1 T 0.54 0.57 136 0.010 0.001 2.0 × 10−36 −0.015 0.010 0.11
rs7965584e ATP2B1 12 A 0.71 0.25 60 0.007 0.001 1.1 × 10−16 −0.016 0.011 0.13
rs3925584 DCDC5 11 T 0.55 0.25 60 0.006 0.001 5.2 × 10−16 −0.016 0.010 0.09
rs11144134 TRPM6 9 C 0.08 0.23 55 0.011 0.001 8.2 × 10−15 0.039 0.019 0.04
rs13146355 SHROOM3 4 A 0.44 0.19 45 0.005 0.001 6.3 × 10−13 −0.003 0.010 0.76
rs448378 MDS1 3 A 0.53 0.13 30 0.004 0.001 1.3 × 10−8 −0.017 0.009 0.06
  1. CAD coronary artery disease, Chr chromosome, EA effect allele, EAF effect allele frequency, SE standard error, SNP single-nucleotide polymorphism
  2. aBeta coefficients and standard errors were obtained from genome-wide association studies on serum magnesium (23,829 individuals) [22] and CAD (60,801 cases and 123,504 non-cases) [23]
  3. bAllele associated with higher serum magnesium levels
  4. cFrequency of the magnesium-raising allele in the magnesium genome-wide association study [22]
  5. dLog odds ratio of CAD for each additional magnesium-increasing allele
  6. eProxy (rs10858938; r2 = 0.96 in European descent individuals) was used in the CAD data