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Table 4 High throughput screening for potential compounds with anti-Zika activity (drug repurposing)

From: Zika vaccines and therapeutics: landscape analysis and challenges ahead

Study

No. of drugs screened

Compounds identified with anti-Zika activity

Remarks

Barrows et al. [54]

774 FDA-approved agents

Clofazimine, Digoxin, Gemcitabine, Ivermectin, Mefloquine, Mercaptopurine hydrate, Mycophenolic acid, Fingolimod, Mycophenolate mofetil, Dactinomycin, Bortezomib, Methoxsalen (Xanthotoxin), Azathioprine, Thioguanine, Auranofin, Sertraline, Pyrimethamine, Daptomycin, Palonosetron, Deferasirox, Micafungin, Sorafenib tosylate, Cyclosporine A, Mebendazole

• Mycophenolic acid (MPA), Ivermectin, Daptomycin, Mefloquine, Palonosetron identified as having higher potency

• Daptomycin, Mefloquine, and Palonosetron are pregnancy category B drugs

Xu et al. [58]

6000 compounds,

> 2000 FDA-approved agents

Niclosamide, Emricasan, 10 structurally unrelated inhibitors of CDK

• Emricasan is an inhibitor of caspase-3 activity but uncertain if a capase-3 inhibitor with anti-inflammatory properties impacts development of unborn fetus