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Table 3 Pregnancy outcomes related to the percentage of blastomere loss following single frozen-thawed embryo transfer

From: Outcomes of neonates born following transfers of frozen-thawed cleavage-stage embryos with blastomere loss: a prospective, multicenter, cohort study

  Percentage of blastomere loss p 1 a p 2 a p 3 a p for trend b
0% (n = 803) ≤ 25% (n = 154) 26–50% (n = 166)
Chemical pregnancies (n, %)c 169(21.1) 35 (22.7) 18 (10.8) 0.641 0.002 0.004 0.018
Clinical pregnancies (n, %)d 145 (18.1) 28 (18.2) 15 (9.0) 0.971 0.004 0.017 0.020
Ongoing pregnancies (n, %)e 120 (14.9) 26 (16.9) 12 (7.2) 0.540 0.008 0.008 0.021
Live births (n, % per embryo transfer cycle)f 114 (14.2) 25 (16.2) 10 (6.0) 0.511 0.004 0.004 0.041
Live births (n, % per clinical pregnancy)g 114 (77.1) 25 (89.3) 10 (66.7) 0.194 0.331 0.104 0.950
Ectopic pregnancies (n, %) 4 (0.5) 0 (0.0) 0 (0.0) 0.380 1.000 NA 0.219
Early miscarriages (n, % per clinical pregnancy) 25 (17.2) 2 (7.7) 3 (17.7) 0.257 0.728 0.324 0.503
Pregnancy termination due to fetal anomaly (n, % per clinical pregnancy) h 1 (0.7) 0 (0.0) 0 (0.0) 1.000 1.000 NA 0.531
  1. NA not accessible
  2. aP values were calculated using Pearson χ2 test or Fisher exact test, p 1 for comparisons between 0% and ≤ 25% group, p 2 for comparisons between 0% and 26–50% group, p 3 for comparisons between ≤ 25% and 26–50% group
  3. bPfor trend was calculated using Cochran–Mantel–Haenszel test, and adjusted for primary infertility and the type of FET cycle
  4. cChemical pregnancy was defined as an elevated serum β-hCG level of more than 10 mIU/mL. Chemical pregnancy rate was defined as the number of chemical pregnancies divided by the number of embryo transfer cycle for each group
  5. dClinical pregnancy was defined as a pregnancy documented by ultrasound at 6–8 gestational weeks that showed a gestational sac in the uterus. Clinical pregnancy rate was defined as the number of clinical pregnancies divided by the number of embryo transfer cycles for each group
  6. eOngoing pregnancy was defined as a pregnancy documented by ultrasound at 12 gestational weeks that showed the presence of fetal heartbeat. Ongoing pregnancy rate was defined as the number of ongoing pregnancies divided by the number of embryo transfer cycles for each group
  7. fLive birth was defined as the delivery of one or more infants with any signs of life after 28 gestational weeks. Live birth rate (% per embryo transfer cycle) was defined as the number of live births divided by the number of embryo transfer cycles for each group
  8. gLive birth rate (% per clinical pregnancy) was defined as the number of live births divided by the number of clinical pregnancies for each group
  9. hOne patient in 0% group terminated the pregnancy due to achondroplasia
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BMC Medicine

ISSN: 1741-7015

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