| |
HBsAg negative
|
HBsAg positive
|
|---|
|
Without hepatitis or cirrhosis
|
With hepatitis or cirrhosis
|
Without hepatitis or cirrhosis
|
With hepatitis or cirrhosis
|
|---|
|
Without treatment
|
With treatment
|
|---|
|
Whole cohort
|
|
Number of cases
|
4339
|
42
|
143
|
19
|
12
|
|
Cases/PY (1000)
|
1.07
|
1.28
|
1.22
|
1.62
|
5.03
|
|
HR (95% CI)
|
1.00
|
0.99 (0.73, 1.35)
|
1.27 (1.08, 1.51)
|
1.57 (1.00, 2.46)
|
4.74 (2.68, 8.36)
|
|
p value
|
–
|
0.961
|
0.004
|
0.052
|
<0.001
|
|
Men
|
|
Number of cases
|
1652
|
19
|
72
|
12
|
7
|
|
Cases/PY (1000)
|
1.02
|
0.99
|
1.41
|
1.86
|
4.26
|
|
HR (95% CI)
|
1.00
|
0.85 (0.54, 1.34)
|
1.63 (1.29, 2.07)
|
2.10 (1.19, 3.72)
|
4.64 (2.20, 9.80)
|
|
p value
|
–
|
0.484
|
<0.001
|
0.011
|
<0.001
|
|
Women
|
|
Number of cases
|
2687
|
23
|
71
|
7
|
5
|
|
Cases/PY (1000)
|
1.11
|
1.69
|
1.08
|
1.32
|
6.71
|
|
HR (95% CI)
|
1.00
|
1.20 (0.79, 1.81)
|
1.03 (0.82, 1.31)
|
1.15 (0.55, 2.42)
|
5.25 (2.18, 12.66)
|
|
p value
|
–
|
0.390
|
0.775
|
0.712
|
<0.001
|
- CI confidence interval, HBsAg hepatitis virus B surface antigen, HR hazard ratio, PY person-year
- Multivariable model was adjusted for: age (years); sex (men or women, for whole cohort); level of education (no formal school, primary school, middle school, high school, college, or university or higher); marital status (married, widowed, divorced or separated, or never married); alcohol consumption (less than weekly drinker, weekly drinker, daily drinker with an intake of <15, 15–29, 30–59, or ≥60 g/day); smoking status (nonsmoker, former smoker having quit smoking ≥5 or <5 years previously, or current daily smoker smoking <15, 15–24, or ≥25 cigarettes or equivalents per day); physical activity (MET-h/day); intake frequencies of red meat, fresh fruit, and fresh vegetables (daily, 4–6 days/week, 1–3 days/week, monthly, rarely, or never); body mass index (kg/m2); menopausal status (premenopausal, perimenopausal, or postmenopausal; for women only); prevalent diabetes; and prevalent hypertension at baseline (presence or absence)
