Skip to main content

Table 3 HRs (95% CIs) for incident chronic kidney disease according to HBsAg status and presence of chronic hepatitis or cirrhosis and its treatment status at baseline for 469,459 participants

From: Chronic hepatitis B virus infection and risk of chronic kidney disease: a population-based prospective cohort study of 0.5 million Chinese adults

  HBsAg negative HBsAg positive
Without hepatitis or cirrhosis With hepatitis or cirrhosis Without hepatitis or cirrhosis With hepatitis or cirrhosis
Without treatment With treatment
Whole cohort
 Number of cases 4339 42 143 19 12
 Cases/PY (1000) 1.07 1.28 1.22 1.62 5.03
 HR (95% CI) 1.00 0.99 (0.73, 1.35) 1.27 (1.08, 1.51) 1.57 (1.00, 2.46) 4.74 (2.68, 8.36)
p value 0.961 0.004 0.052 <0.001
Men
 Number of cases 1652 19 72 12 7
 Cases/PY (1000) 1.02 0.99 1.41 1.86 4.26
 HR (95% CI) 1.00 0.85 (0.54, 1.34) 1.63 (1.29, 2.07) 2.10 (1.19, 3.72) 4.64 (2.20, 9.80)
p value 0.484 <0.001 0.011 <0.001
Women
 Number of cases 2687 23 71 7 5
 Cases/PY (1000) 1.11 1.69 1.08 1.32 6.71
 HR (95% CI) 1.00 1.20 (0.79, 1.81) 1.03 (0.82, 1.31) 1.15 (0.55, 2.42) 5.25 (2.18, 12.66)
p value 0.390 0.775 0.712 <0.001
  1. CI confidence interval, HBsAg hepatitis virus B surface antigen, HR hazard ratio, PY person-year
  2. Multivariable model was adjusted for: age (years); sex (men or women, for whole cohort); level of education (no formal school, primary school, middle school, high school, college, or university or higher); marital status (married, widowed, divorced or separated, or never married); alcohol consumption (less than weekly drinker, weekly drinker, daily drinker with an intake of <15, 15–29, 30–59, or ≥60 g/day); smoking status (nonsmoker, former smoker having quit smoking ≥5 or <5 years previously, or current daily smoker smoking <15, 15–24, or ≥25 cigarettes or equivalents per day); physical activity (MET-h/day); intake frequencies of red meat, fresh fruit, and fresh vegetables (daily, 4–6 days/week, 1–3 days/week, monthly, rarely, or never); body mass index (kg/m2); menopausal status (premenopausal, perimenopausal, or postmenopausal; for women only); prevalent diabetes; and prevalent hypertension at baseline (presence or absence)
\