Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma

Table 2 Univariate Cox regression for cancer-specific survival in the extended clear cell renal cell carcinoma cohort 2 (n = 108)

Univariate analyses	Variable	Level	No. of cases	HR (95% CI)	P value	c-index
Univariate analyses	Variable	Level	No. of cases	HR (95% CI)	(Log-rank test)	c-index
All patients	S3₁₅-score	high	87	1 (Ref.)	5.15 × 10^–5	0.69
		low	21	4.96 (2.10–11.72)
M0	S3₁₅-score	high	77	1 (Ref.)	1.62 × 10^–2	0.68
		low	15	4.37 (1.17–16.29)
M1	S3₁₅-score	high	9	1 (Ref.)	2.31 × 10^–3	0.71
		low	6	9.32 (1.75–49.58)

CI confidence interval, HR hazard ratio, Ref. reference level
S3₁₅-scores were determined based on gene expression data measured by RT-PCR; tumors with metastasis status MX were disregarded

ISSN: 1741-7015