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Table 3 Multivariate Cox regression for cancer-specific survival in the extended ccRCC cohort 2 (n = 108)

From: Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma

Multivariate analyses

variable

level

P-value

HR (95%CI)

(Wald test)

Including T,N,M,G and S315-score

S315-score

high

 

1 (Ref.)

  

low

0.00033

7.3 (2.5–21.5)

 

Primary tumor

T1

 

1 (Ref.)

  

T2

0.37

3.0 (0.3–35.0)

  

T3

0.01

6.0 (1.5–24.3)

 

Lymph Nodes

N0

 

1 (Ref.)

  

N1

0.25

0.5 (0.1–1.7)

  

N2

0.45

0.4 (0.0–3.9)

 

Distant metastasis

M0

 

1 (Ref.)

  

M1

0.00001

23.5 (6.0–92.2)

 

Fuhrman grade

G1

 

1 (Ref.)

  

G2

0.73

1.5 (0.2–14.1)

  

G3

0.93

0.9 (0.1–10.3)

  1. Abbreviations: CI confidence interval, HR hazard ratio, Ref. reference level. S315-scores were determined based on gene expression data measured by RT-PCR; T, primary tumor; N, regional lymph node; M, distant metastasis present at diagnosis; G, grading; tumors with grade “G2–3” and “G4” were added to “G3”. Tumors with no grading information or metastasis status “MX” were disregarded