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Table 3 Multivariate Cox regression for cancer-specific survival in the extended ccRCC cohort 2 (n = 108)

From: Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma

Multivariate analyses variable level P-value HR (95%CI)
(Wald test)
Including T,N,M,G and S315-score S315-score high   1 (Ref.)
   low 0.00033 7.3 (2.5–21.5)
  Primary tumor T1   1 (Ref.)
   T2 0.37 3.0 (0.3–35.0)
   T3 0.01 6.0 (1.5–24.3)
  Lymph Nodes N0   1 (Ref.)
   N1 0.25 0.5 (0.1–1.7)
   N2 0.45 0.4 (0.0–3.9)
  Distant metastasis M0   1 (Ref.)
   M1 0.00001 23.5 (6.0–92.2)
  Fuhrman grade G1   1 (Ref.)
   G2 0.73 1.5 (0.2–14.1)
   G3 0.93 0.9 (0.1–10.3)
  1. Abbreviations: CI confidence interval, HR hazard ratio, Ref. reference level. S315-scores were determined based on gene expression data measured by RT-PCR; T, primary tumor; N, regional lymph node; M, distant metastasis present at diagnosis; G, grading; tumors with grade “G2–3” and “G4” were added to “G3”. Tumors with no grading information or metastasis status “MX” were disregarded