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Fig. 2 | BMC Medicine

Fig. 2

From: Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial

Fig. 2

a Number of dose titrations within first 2 weeks of therapy. Dark horizontal lines indicate median values. The circle represents the mean. The top line of the box indicates the 75th percentile, and the bottom line of the box indicates the 25th percentile. The top and bottom whiskers indicate the 97.5th and 2.5th percentiles, respectively. b Non-inferiority and superiority comparison for the primary endpoint of mean difference in number of dose titrations within first 2 weeks of therapy. Error bars indicate two-sided 90% or 95% CI, respectively. Since the upper bound of the 90% CI of the difference in treatment (genotype-guided vs. traditional dosing) was less than 0.5, the genotype-guided strategy was non-inferior to the traditional dosing approach. The upper bound of the 95% CI did not exceed 0, indicating that superiority was also demonstrated

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