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Table 2 Cost of disease and vaccination parameters of the economic model. We report the base case values and the standard deviations, taken either from the literature or from administrative data, the shapes of the prior distribution, the 95% CI from the posterior distribution of the parameters, and the source of the base case values

From: The impact of demographic changes, exogenous boosting and new vaccination policies on varicella and herpes zoster in Italy: a modelling and cost-effectiveness study

Parameter

Base case values (EUR)

Standard deviation (EUR)

Prior Distribution

95% CI

Posterior distribution

Source

Cost of disease parameters

 GP consultation cost for NVa

  < 14 years

29.07

2.05

Gamma

[25.14–33.27]

[64]

  ≥ 15 years

19.00

1.25

Gamma

[16.65–21.53]

[65]

 GP treatment cost for NVa

  < 14 years

13.64

1.61

Gamma

[10.72–16.96]

[66]

  ≥ 15 years

26.10

2.00

Gamma

[22.35–30.14]

[65]

 Hospitalisation cost for NV

  < 14 years

2683.25

1780.56

Gamma

[411.80–7128.02]

Hospital Discharge Register (HDR) Lombardy

  ≥ 15 years

2720.29

2573.64

Gamma

[348.73–9463.01]

HDR Lombardy

 Outpatient cost for HZ (incl. Visit, treatment, and diagnostics)a

144.03

114.48

Gamma

[11.53–438.21]

[2]

 Outpatient cost for PHN (incl. Visit, treatment, and diagnostics)a

523.72

520.05

Gamma

[13.95–1905.90]

[2]

 Hospitalisation cost for HZ

  < 49 years

2073.50

2260.35

Gamma

[176.35–8238.92]

HDR Lombardy

  ≥50 years

2020.23

1332.60

Gamma

[307.63–5313.47]

HDR Lombardy

 Hospitalisation cost for PHN

  < 49 years

1500.74

1714.41

Gamma

[78.93–6132.75]

HDR Lombardy

  ≥50 years

1927.25

1892.80

Gamma

[75.02–7058.80]

 

Vaccination parameters

 Cost per dose of varicella vaccination

31.46

 

Fixed

Purchase priceb

 Cost per dose of HZ vaccination

87.00

 

Fixed

Invitation for bid

 Admin. cost per dose of vaccinationa

7.56

 

Fixed

[59]

  1. aThese costs are adjusted for the inflation at 2015, using the Italian Consumer Price Index
  2. bPurchase price of the vaccine for varicella per dose, paid by Lombardy Regional Health System