The impact of demographic changes, exogenous boosting and new vaccination policies on varicella and herpes zoster in Italy: a modelling and cost-effectiveness study

Table 2 Cost of disease and vaccination parameters of the economic model. We report the base case values and the standard deviations, taken either from the literature or from administrative data, the shapes of the prior distribution, the 95% CI from the posterior distribution of the parameters, and the source of the base case values

Parameter	Base case values (EUR)	Standard deviation (EUR)	Prior Distribution	95% CI Posterior distribution	Source
Cost of disease parameters
GP consultation cost for NV^a
< 14 years	29.07	2.05	Gamma	[25.14–33.27]	[64]
≥ 15 years	19.00	1.25	Gamma	[16.65–21.53]	[65]
GP treatment cost for NV^a
< 14 years	13.64	1.61	Gamma	[10.72–16.96]	[66]
≥ 15 years	26.10	2.00	Gamma	[22.35–30.14]	[65]
Hospitalisation cost for NV
< 14 years	2683.25	1780.56	Gamma	[411.80–7128.02]	Hospital Discharge Register (HDR) Lombardy
≥ 15 years	2720.29	2573.64	Gamma	[348.73–9463.01]	HDR Lombardy
Outpatient cost for HZ (incl. Visit, treatment, and diagnostics)^a	144.03	114.48	Gamma	[11.53–438.21]	[2]
Outpatient cost for PHN (incl. Visit, treatment, and diagnostics)^a	523.72	520.05	Gamma	[13.95–1905.90]	[2]
Hospitalisation cost for HZ
< 49 years	2073.50	2260.35	Gamma	[176.35–8238.92]	HDR Lombardy
≥50 years	2020.23	1332.60	Gamma	[307.63–5313.47]	HDR Lombardy
Hospitalisation cost for PHN
< 49 years	1500.74	1714.41	Gamma	[78.93–6132.75]	HDR Lombardy
≥50 years	1927.25	1892.80	Gamma	[75.02–7058.80]
Vaccination parameters
Cost per dose of varicella vaccination	31.46		Fixed	–	Purchase price^b
Cost per dose of HZ vaccination	87.00		Fixed	–	Invitation for bid
Admin. cost per dose of vaccination^a	7.56		Fixed	–	[59]

^aThese costs are adjusted for the inflation at 2015, using the Italian Consumer Price Index
^bPurchase price of the vaccine for varicella per dose, paid by Lombardy Regional Health System

ISSN: 1741-7015