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Table 2 Cost of disease and vaccination parameters of the economic model. We report the base case values and the standard deviations, taken either from the literature or from administrative data, the shapes of the prior distribution, the 95% CI from the posterior distribution of the parameters, and the source of the base case values

From: The impact of demographic changes, exogenous boosting and new vaccination policies on varicella and herpes zoster in Italy: a modelling and cost-effectiveness study

Parameter Base case values (EUR) Standard deviation (EUR) Prior Distribution 95% CI
Posterior distribution
Source
Cost of disease parameters
 GP consultation cost for NVa
  < 14 years 29.07 2.05 Gamma [25.14–33.27] [64]
  ≥ 15 years 19.00 1.25 Gamma [16.65–21.53] [65]
 GP treatment cost for NVa
  < 14 years 13.64 1.61 Gamma [10.72–16.96] [66]
  ≥ 15 years 26.10 2.00 Gamma [22.35–30.14] [65]
 Hospitalisation cost for NV
  < 14 years 2683.25 1780.56 Gamma [411.80–7128.02] Hospital Discharge Register (HDR) Lombardy
  ≥ 15 years 2720.29 2573.64 Gamma [348.73–9463.01] HDR Lombardy
 Outpatient cost for HZ (incl. Visit, treatment, and diagnostics)a 144.03 114.48 Gamma [11.53–438.21] [2]
 Outpatient cost for PHN (incl. Visit, treatment, and diagnostics)a 523.72 520.05 Gamma [13.95–1905.90] [2]
 Hospitalisation cost for HZ
  < 49 years 2073.50 2260.35 Gamma [176.35–8238.92] HDR Lombardy
  ≥50 years 2020.23 1332.60 Gamma [307.63–5313.47] HDR Lombardy
 Hospitalisation cost for PHN
  < 49 years 1500.74 1714.41 Gamma [78.93–6132.75] HDR Lombardy
  ≥50 years 1927.25 1892.80 Gamma [75.02–7058.80]  
Vaccination parameters
 Cost per dose of varicella vaccination 31.46   Fixed Purchase priceb
 Cost per dose of HZ vaccination 87.00   Fixed Invitation for bid
 Admin. cost per dose of vaccinationa 7.56   Fixed [59]
  1. aThese costs are adjusted for the inflation at 2015, using the Italian Consumer Price Index
  2. bPurchase price of the vaccine for varicella per dose, paid by Lombardy Regional Health System