Fig. 1
From: Modelling population-level impact to inform target product profiles for childhood malaria vaccines
Profiles for three points on the α-β curve, where the area under the efficacy-time curve is held constant. Red solid line α = 0.40, β = 615.06, Vmax = 0.93 (lower initial efficacy, longer duration). Blue dashed line α = 0.74, β = 99.20, Vmax = 0.93 (RTS,S/AS01 phase 3 trial modelled parameters). Green dash-dotted line α = 1.00, β = 60.56, Vmax = 0.93 (higher initial efficacy, shorter duration). The corresponding antibody titre curve for the intermediate scenario is shown in Additional file 1: Figure S2, and the role of the shape parameter α and scale parameter β is illustrated in Additional file 1: Figure S10