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Fig. 3 | BMC Medicine

Fig. 3

From: Modelling population-level impact to inform target product profiles for childhood malaria vaccines

Fig. 3

Impact of varying the timing and antibody titre of the fourth vaccine dose. a Cumulative clinical cases averted over a 10-year period in 0–5-year-old children, for a range of antibody titre and fourth dose timing values, where PfPR2–10 = 30%. b Efficacy curves corresponding to the timing-titre parameter pairs indicated in panel a. c Cumulative clinical cases averted over a 10-year period in 0–5-year-old children, stratified by prevalence setting and efficacy profile. d Cumulative clinical cases averted over a 10-year period per 1000 individuals for 1-year age groups, where PfPR2–10 = 30%. In c and d, the bars show the median estimates and the error bars show 95% credible intervals, based on 50 parameter draws. PfPR2–10 represents P. falciparum prevalence for 2–10-year-old individuals, prior to vaccination

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