Titrate sertraline up to 50 mg/day by week 3 | Titrate sertraline up to 100 mg/day by week 3 | 100 mg/day vs 50 mg/day | |
---|---|---|---|
Least squares mean (95% CI) | Least squares mean (95% CI) | Adjusteda difference (95% CI) P value | |
PHQ-9 | 7.90 (7.14 to 8.66) | 8.15 (7.78 to 8.52) | 0.25 (−0.58 to 1.07) P = 0.55 |
BDI-II | 16.55 (15.43 to 17.67) | 16.00 (14.88 to 17.13) | −0.55 (−2.09 to 1.00) P = 0.49 |
FIBSER | 5.03 (4.81 to 5.26) | 5.28 (4.96 to 5.61) | 0.25 (− 0.15 to 0.65), P = 0.22 |
Raw numbers | Raw numbers | Adjustedb OR (95% CI) P value | |
Proportion of response | 216/424 (111 of 251 who were unremitted and allocated to continue sertraline, 91 of 129 who remitted and continued on sertraline and 14 out of 44 who withdrew from protocol) | 229/425 (122 of 286 who were unremitted and allocated to continue sertraline, 84 of 99 who remitted and continued on sertraline and 23 out of 40 who withdrew from protocol) | 1.23 (0.90 to 1.67), P = 0.19 |
Proportion of remission | 185/424 (64 of 251 who were unremitted and allocated to continue sertraline, 110 of 129 who remitted and continued on sertraline and 11 out of 44 who withdrew from protocol) | 170/426 (68 of 286 who were unremitted and allocated to continue sertraline, 86 of 99 who remitted and continued on sertraline and 16 out of 41 who withdrew from protocol) | 1.09 (0.75 to 1.58), P = 0.64 |
Proportion of continuation of the allocated treatment up to week 9 | 302/460 (204 of 261 who were unremitted and allocated to continue sertraline, 96 of 129 who remitted and continued on sertraline and 2 out of 70 who withdrew from protocol) | 330/455 (248 of 290 who were unremitted and allocated to continue sertraline, 80 of 101 who remitted and continued on sertraline and 2 out of 64 who withdrew from protocol) | 1.17 (0.70 to 1.98) P = 0.53 |
Mean (SD) | Mean (SD) | ||
Sertraline prescribed at week 9 (mg/day) | 45.5 (19.8), n = 384 | 85.3 (32.1), n = 391 |