Table 2 Descriptive characteristics of patients with an incident diagnosis of NAFLD in four European primary-care databases
From: Real-world data reveal a diagnostic gap in non-alcoholic fatty liver disease
Characteristics | HSD (N = 24,027) | IPCI (N = 18,865) | SIDIAP (N = 77,107) | THIN (N = 23,385) | Test of difference p value |
|---|---|---|---|---|---|
% / Mean (SD) / median (IQR) | % / Mean (SD) / median (IQR) | % / Mean (SD) / median (IQR) | % / Mean (SD) / median (IQR) | Â | |
Age in years | 56.2 (14.3) | 56.8 (13.9) | 56.0 (13.4) | 53.7 (13.4) | <0.0001 |
Gender (males) | 57.3% | 49.3% | 52.7% | 51.5% | <0.0001 |
Body mass index in kg/m2 | 29.7 (5.0) | 30.8 (5.4) | 31.3 (5.1) | 32.4 (5.9) | <0.0001 |
History of diabetes or impaired fasting glucose | 18.0% | 20.5% | 20.0% | 21.0% | <0.0001 |
History of hypertension | 47.5% | 36.0% | 42.8% | 40.5% | <0.0001 |
Aspartate transaminase (IU/L) | 24 (19–33) | 29 (22–40) | 29 (22–40) | 32 (24–47) | <0.0001 |
Alanine transaminase (IU/L) | 30 (20–48) | 37 (25–56) | 34 (22–53) | 45 (28–68) | <0.0001 |
Platelet counts (109/L) | 238 (65) | 262 (68.6) | 244 (61.2) | 250 (75.3) | <0.0001 |
AST to ALT ratio | 0.87 (0.34) | 0.80 (0.36) | 0.83 (0.38) | 0.82 (0.38) | <0.0001 |
FIB-4 score | Â | Â | Â | Â | <0.0001 |
 Low risk (FIB-4 < 1.30) | 64.3% | 70.4% | 65.5% | 65.0% |  |
 Indeterminate risk (FIB-4: 1.30–2.67) | 31.4% | 26.7% | 30.3% | 25.0% |  |
 High risk (FIB-4 > 2.67) | 4.3% | 2.9% | 4.2% | 10.0% |  |