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Table 1 Summary characteristics of included systematic reviews and the randomised controlled trial data captured by the reviews

From: Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments

Characteristic Reviews
n (%)
Review level information (n = 140)
 Cochrane reviews 49 (35)
 Number of unique medications investigateda 100
 Number of unique patient populations investigatedb 47
 Reviews focusing on medications for patients with chronic diseases 125 (89)
 Patient populationc
  Diseases of the respiratory system 56 (40)
  Diseases of the circulatory system 53 (38)
  Factors influencing health status and contact with health servicesd 8 (6)
  Diseases of the digestive system 8 (6)
  Mental and behavioural disorders 7 (5)
  Diseases of the genitourinary system 5 (4)
  Pregnancy, childbirth and puerperium 5 (4)
  Endocrine, nutritional and metabolic diseases 5 (4)
  Mixed patient populations 3 (2)
  Multi-morbidity 2 (1)
  Othere 4 (3)
 Hospitalisation was a primary outcome 61 (44)
 Review reported pooled effect estimates showing significant reductions in hospital admissions 78 (56)
 AMSTAR score for review quality, median (IQR) 8 (6 to 9)
 Review year of publication  
  2010–2016 96 (69)
  2000–2009 42 (30)
  1991–1999 2 (1)
Randomised controlled trial (RCT) information
 Number of unique RCTs 1968
 Number of unique patients 925,364
 Number of unique RCTs reporting admissions data 690
 Number of unique patients with admissions data 577,604
 Number of patients per RCT reporting hospital admission outcomes, median (IQR) 190 (62 to 603)
 Number of treatment comparisons reporting hospital admission outcomes 517
  1. AMSTAR Assessing the Methodological Quality of Systematic Reviews, IQR interquartile range, RCT randomised controlled trial
  2. aUnique at the level of pharmacological subgroup in the World Health Organization’s Anatomical Therapeutic Chemical classification system
  3. bUnique at the three-character coding level using the 10th revision of the World Health Organization’s International Statistical Classification of Diseases and Related Health Problems (ICD-10)
  4. cThese specific classifications represent the summary level of coding in ICD-10
  5. dFor example, patients receiving day surgery
  6. eInfection and parasitic disease (n = 1 review), diseases of the musculoskeletal system and connective tissue (n = 1 review), and diseases of the nervous system (n = 2 reviews)