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Table 2 Details of tests used in the algorithms

From: Fast and expensive (PCR) or cheap and slow (culture)? A mathematical modelling study to explore screening for carbapenem resistance in UK hospitals

Test

Negative result

Sensitivity

Specificity

References and notes

Screening algorithm

(A) Direct PCR

(B) Culture + PCR

(C) PHE

PCR from swab

S

96%

99%

Tato et al., 2016 [27]

x

  

ICHNT PCR

NCP-CREa

98%

99%

ICHNT data

 

x

x

Culture (1)

S

89%

91%

ICHNT data

 

x

x

Culture (2)

NCP-CRE

100%

85%

ICHNT data

 

x

x

PHE PCR

NCP-CREa

100%

100%

Assumed optimal

  

x

  1. Sensitivity is the probability that the test detects resistance given that the patient carries resistant Enterobacteriaceae. Specificity is the probability of a negative test for resistance given that the patient does not carry resistant bacteria
  2. aAs both of these PCR tests are on samples that have shown to be culture positive for CRE, they are classified as NCP-CRE if the PCR test for CPE is negative