Screening algorithm | Scenario | Outcomes | ||||||
---|---|---|---|---|---|---|---|---|
Speciality | Screening coverage | CP-CRE prevalence | Number of “days at risk” | Total isolation bed days | Total isolation bed days of patients without CP-CRE | Cost per risk day averted (£) | Average incremental cost per additional averted risk day (£) | |
(A) Direct PCR | ICU | 100% | 1.6% | 90 (4.39) | 1500 (19.25) | 368 (94.96) | 198.45 | 743.56 |
63% | 1.6% | 508 (14.83) | 991 (17.98) | 244 (72.30) | 192.18 | 712.38 | ||
63% | 20% | 5080 (36.20) | 7649 (50.40) | 173 (58.47) | 58.18 | 97.10 | ||
100% | 20% | 918 (14.39) | 11,834 (49.99) | 263 (85.91) | 58.69 | 99.57 | ||
(B) Culture +PCR | 100% | 1.6% | 335 (9.31) | 910 (17.59) | 3 (5.55) | 63.05 | – | |
63% | 1.6% | 642 (14.06) | 600 (15.84) | 4 (10.01) | 61.38 | – | ||
63% | 20% | 6664 (42.32) | 5955 (38.82) | 17 (20.84) | 48.09 | – | ||
100% | 20% | 3308 (24.68) | 9282 (53.2) | 29 (38.32) | 48.44 | – | ||
(C) PHE | 100% | 1.6% | 221 (3.74) | 1024 (19.37) | 28 (31.95) | 83.18 | 288.63 | |
63% | 1.6% | 655 (14.00) | 623 (17.57) | 13 (18.32) | 78.69 | 819.56 | ||
63% | 20% | 5194 (31.49) | 7465 (45.2) | 17 (21.47) | 48.05 | 47.90 | ||
100% | 20% | 2309 (11.15) | 10,287 (51.71) | 41 (38.09) | 49.68 | 61.23 |