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Table 1 Two-stage regression coefficients for Mendelian randomisation analysis using genetic risk score in individual level data

From: Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

 

GRS-25OHD coefficient (95% CI)b

GRS-CRC coefficient (95% CI)c

SOCCS controls

Scotland 1

SOCCS/GS

Croatia

SOCCS/LBC

UK biobank

Univariable model

 Weighted score

0.055 (0.039 to 0.071)

0.036 (−0.055 to 0.128)

− 0.009 (− 0.045 to 0.026)

0.072 (− 0.048 to 0.191)

− 0.029 (− 0.133 to 0.076)

− 0.022 (− 0.061 to 0.017)

 Unweighted score

0.046 (0.031 to 0.062)

0.037 (−0.055 to 0.128)

− 0.005 (− 0.041 to 0.030)

0.110 (− 0.010 to 0.230)

0.001 (− 0.104 to 0.106)

− 0.008 (− 0.047 to 0.031)

Multivariable modela

 Weighted score

0.057 (0.040 to 0.073)

0.109 (−0.011 to 0.230)

− 0.026 (− 0.081 to 0.029)

0.074 (− 0.047 to 0.194)

− 0.031 (− 0.136 to 0.074)

− 0.024 (− 0.047 to 0.031)

 Unweighted score

0.051 (0035 to 0.068)

0.080 (−0.038 to 0.197)

− 0.022 (− 0.077 to 0.032)

0.114 (− 0.007 to 0.235)

− 0.003 (− 0.108 to 0.102)

− 0.011 (− 0.050 to 0.029)

  1. aMultivariable regression model adjusted by age, sex and BMI for Scotland 1, SOCCS/GS and UK biobank, age and sex for Croatia, sex for LBC.MD
  2. bChange in log-transformed 25-OHD (nmol/L) per unit increase in GRS
  3. cChange in logit CRC risk per unit increase in GRS
  4. 25-OHD 25-hydroxyvitamin D, CI confidence interval, CRC colorectal cancer, GRS genetic risk score, LBC Lothian Birth Cohort, SOCCS Scotland Colorectal Cancer Study