Table 1 Demographic and clinical characteristics of patients with stages I–II and III–IV pancreatic cancer
Parameter | USA (2004–2013) | The Netherlands (2003–2014) | Belgium (2004–2013) | Norway (2003–2014) | Slovenia (2003–2013) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Group | Overall | Resected | Overall | Resected | Overall | Resected | Overall | Resected | Overall | Resected |
Stages I–II | ||||||||||
Number (n) | 31,313 | 13,303 (43) | 5710 | 2675 (47) | 3437 | 2155 (63) | 1545 | 526 (34) | 667 | 406 (61) |
Microscopically confirmed | 27,290 (87) | 13,290 (> 99) | 4046 (71) | 2673 (> 99) | 3127 (91) | 2148 (> 99) | 1017 (66) | 520 (99) | 475 (71) | 401 (99) |
Gender, female | 16,193 (52) | 6604 (50) | 2951 (52) | 1268 (47) | 1684 (49) | 993 (46) | 853 (55) | 261 (50) | 361 (54) | 209 (52) |
Age, years | 70 ± 12 | 66 ± 11 | 71 ± 11 | 65 ± 10 | 69 ± 11 | 66 ± 10 | 72 ± 12 | 65 ± 11 | 69 ± 11 | 65 ± 10 |
Age group | ||||||||||
< 60 years | 6100 (20) | 3574 (27) | 981 (17) | 693 (26) | 686 (20) | 546 (25) | 234 (15) | 134 (26) | 144 (22) | 122 (30) |
60–69 years | 7817 (25) | 4272 (32) | 1477 (26) | 978 (37) | 937 (27) | 698 (32) | 375 (24) | 195 (37) | 166 (25) | 131 (32) |
≥ 70 years | 17,396 (56) | 5457 (41) | 3252 (57) | 1004 (38) | 1814 (53) | 911 (42) | 936 (61) | 197 (37) | 357 (54) | 153 (38) |
Tumor locationa | ||||||||||
Pancreas head | 22,412 (83) | 9573 (80) | 4666 (89) | 2187 (89) | 1807 (81) | 1207 (82) | 851 (85) | 394 (84) | 471 (88) | 321 (87) |
Pancreas body | 2502 (9) | 890 (8) | 255 (5) | 91 (4) | 179 (8) | 100 (7) | 87 (9) | 33 (7) | 35 (7) | 26 (7) |
Pancreas tail | 2196 (8) | 1448 (12) | 296 (6) | 191 (8) | 244 (11) | 169 (11) | 62 (6) | 41 (9) | 32 (6) | 21 (6) |
Other | 4203 (13) | 1392 (11) | 493 (9) | 206 (8) | 1207 (35) | 679 (32) | 545 (35) | 58 (11) | 129 (19) | 38 (9) |
Differentiationb | ||||||||||
Well | 2145 (13) | 1428 (12) | 283 (12) | 244 (11) | 389 (18) | 302 (17) | 61 (10) | 27 (6) | 41 (10) | 37 (10) |
Intermediate | 7574 (47) | 6026 (51) | 1225 (51) | 1138 (52) | 1072 (48) | 901 (50) | 352 (55) | 259 (61) | 153 (37) | 142 (38) |
Poor/undifferentiated | 6264 (39) | 4464 (38) | 920 (38) | 802 (37) | 762 (34) | 608 (34) | 223 (35) | 135 (32) | 221 (53) | 192 (52) |
Neoadjuvant chemotherapy | – | NA | – | 50 (2) | – | 53 (3) | – | NA | – | 2 (1) |
Neoadjuvant radiotherapy | – | 522 (4) | – | 34 (1) | – | 20 (1) | – | 0 (0) | – | 1 (< 1) |
Resection type | ||||||||||
Pancreatoduodenectomy | – | 9479 (71) | – | 2269 (85) | – | NA | – | NA | – | NA |
Distal pancreatectomy | – | 1878 (14) | – | 256 (10) | – | NA | – | NA | – | NA |
Total pancreatectomy | – | 1629 (12) | – | 42 (2) | – | NA | – | NA | – | NA |
Otherc | – | 314 (2) | – | 108 (4) | – | NA | – | NA | – | NA |
Adjuvant/palliative chemotherapy | NA | NA | 1392 (24) | 1078 (40) | 1796 (52) | 1200 (56) | 265 (17) | 127 (24) | 131 (20) | 120 (30) |
Adjuvant/palliative radiotherapy | 4460 (14) | 4193 (32) | 120 (2) | 33 (1) | 326 (10) | 190 (9) | 64 (4) | 17 (3) | 9 (1) | 8 (2) |
Stages III–IV | ||||||||||
Number (n) | 55,153 | 1998 (4) | 13,974 | 237 (2) | 5632 | 298 (5) | 4633 | 108 (2) | 1997 | 135 (7) |
Microscopically confirmed | 46,973 (85) | 1994 (> 99) | 10,375 (74) | 237 (100) | 4837 (86) | 297 (> 99) | 3224 (70) | 105 (97) | 1056 (53) | 124 (92) |
Gender, female | 26,427 (48) | 969 (49) | 6755 (48) | 106 (45) | 2700 (48) | 154 (52) | 2332 (50) | 47 (44) | 967 (48) | 56 (42) |
Age, years | 69 ± 12 | 65 ± 12 | 68 ± 11 | 64 ± 10 | 69 ± 11 | 64 ± 10 | 71 ± 12 | 64 ± 10 | 69 ± 11 | 65 ± 10 |
Age group | ||||||||||
< 60 years | 12,582 (23) | 636 (32) | 2938 (21) | 69 (29) | 1043 (19) | 92 (31) | 759 (16) | 32 (30) | 393 (20) | 40 (30) |
60–69 years | 15,081 (27) | 622 (31) | 4412 (32) | 96 (41) | 1608 (29) | 103 (35) | 1268 (27) | 43 (40) | 513 (26) | 45 (33) |
≥ 70 years | 27,490 (50) | 740 (37) | 6624 (47) | 72 (30) | 2981 (53) | 103 (35) | 2606 (56) | 26 (24) | 1091 (55) | 43 (32) |
Tumor locationa | ||||||||||
Pancreas head | 21,244 (56) | 1069 (66) | 7202 (62) | 166 (79) | 1585 (58) | 126 (69) | 1245 (63) | 57 (66) | 653 (64) | 80 (78) |
Pancreas body | 7893 (21) | 168 (10) | 1844 (16) | 11 (5) | 508 (19) | 19 (10) | 340 (17) | 8 (9) | 160 (16) | 12 (12) |
Pancreas tail | 9003 (24) | 381 (24) | 2666 (23) | 34 (16) | 649 (24) | 37 (20) | 382 (19) | 21 (24) | 215 (21) | 10 (10) |
Other | 17,013 (31) | 380 (19) | 2262 (16) | 26 (11) | 2890 (51) | 116 (39) | 2666 (58) | 22 (20) | 969 (49) | 33 (24) |
Differentiationd | ||||||||||
Well | 1213 (10) | 173 (11) | 222 (9) | 20 (11) | 425 (17) | 42 (17) | 122 (8) | 6 (7) | 33 (8) | 6 (7) |
Intermediate | 4518 (35) | 680 (45) | 833 (35) | 98 (51) | 962 (39) | 113 (47) | 596 (40) | 50 (61) | 112 (25) | 30 (34) |
Poor/undifferentiated | 6795 (56) | 670 (44) | 1340 (56) | 73 (38) | 1082 (44) | 88 (36) | 765 (52) | 26 (32) | 297 (67) | 52 (59) |
Neoadjuvant chemotherapy | – | NA | – | 15 (6) | – | 24 (8) | – | NA | – | 0 (0) |
Neoadjuvant radiotherapy | – | 139 (7) | – | 5 (2) | – | 9 (3) | – | 0 (0) | – | 0 (0) |
Resection type | ||||||||||
Pancreatoduodenectomy | – | 1140 (57) | – | 178 (75) | – | NA | – | NA | – | NA |
Distal pancreatectomy | – | 295 (15) | – | 39 (17) | – | NA | – | NA | – | NA |
Total pancreatectomy | – | 211 (11) | – | 5 (2) | – | NA | – | NA | – | NA |
Otherc | – | 352 (18) | – | 15 (6) | – | NA | – | NA | – | NA |
Adjuvant/palliative chemotherapy | NA | NA | 3475 (25) | 81 (34) | 3661 (65) | 195 (65) | 1159 (25) | 25 (23) | 368 (18) | 39 (29) |
Adjuvant/palliative radiotherapy | 770 (1) | 383 (19) | 328 (2) | 7 (3) | 358 (6) | 35 (12) | 198 (4) | 4 (4) | 46 (2) | 5 (4) |