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Table 4 Multivariate models showing independent association of sera proteomes and phosphorylated protein in liver associated with advanced liver fibrosis and a higher percentage of collagen

From: An exploratory study examining how nano-liquid chromatography–mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease

Independent predictors of advanced liver fibrosis

Predictor

Odds ratio

Lower 95% CI

Upper 95% CI

Model with RPMA proteinsa

 AST, per 1 U/L

1.037

1.006

1.07*

 Tyk2 Y1054/1055, per 1 unit

1.458

1.177

1.807***

 ALDH, per 1 unit

0.873

0.783

0.973*

Model with MS proteins

 Apolipoprotein C-II precursor, per 1 unit

0.757

0.612

0.936*

 Apolipoprotein A-I preproprotein, per 1 unit

1.086

1.036

1.138***

 Vitamin K-dependent protein S preproprotein, per 1 unit

1.591

1.221

2.071***

Independent predictors of higher percentage collagen

 

Beta

Std. err.

Model with RPMA proteinsa

 ASK1 S83, per 1 unit

− 0.654

0.280*

 Met Y1234/1235, per 1 unit

0.450

0.167**

 p38 MAPK T180/Y182, per 1 unit

0.290

0.072***

 IL-10, per 1 unit

1.197

0.255***

 LIMK1 T508/LIMK2 T505, per 1 unit

− 0.386

0.130**

Model with MS proteins

 Alpha-2-macroglobulin precursor, per 1 unit

0.100

0.026***

 Coagulation factor V precursor, per 1 unit

− 0.159

0.062*

  1. a Liver tissue RPMA proteins were divided by 1000, MS proteins multiplied by 100 for presentation purposes
  2. *p < 0.05, **p < 0.01, ***p < 0.001