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Table 5 Correlations between hepatic phosphoproteins and serum proteins in NASH with advanced fibrosis and a higher percentage of hepatic collagen deposition in the liver

From: An exploratory study examining how nano-liquid chromatography–mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease

Serum proteome by LC-MS

Alpha-2-macroglobulin precursor

Coagulation factor V precursor

Apolipoprotein A-I preproprotein

Apolipoprotein C-II precursor

Vitamin K-dependent protein S preproprotein

Phosphoproteins from RPMA

ρ

ρ

ρ

ρ

ρ

ASK1 S83

0.25132*

− 0.27301*

0.25187*

0.18546

− 0.004

Met

Y1234/1235

0.42158***

− 0.32161**

0.3759**

0.08211

0.2009

p38 MAPK

T180/Y182

0.23536*

− 0.37073**

0.814

0.22551

− 0.1066

IL-10

0.27903*

− 0.38985***

0.2616*

0.11275

− 0.859

LIMK1

T508/

LIMK2

T505

0.39353***

− 0.3773

0.3206**

0.33034**

− 0.2423*

Tyk2

Y1054/1055

0.41652***

− 0.167

0.18053

0.01864

0.0099

ALDH

− 0.07782

− 0.004

− 0.275

0.109

− 0.020

  1. p values < 0.05 are considered significant; *p < 0.05, **p < 0.01, ***p < 0.001