Fig. 1

Determination of the lowest effective dose (LED). Parasitemia trends from individual NSG mice that each received a unique dose of (a) 0.6 mg/kg, 0.3 mg/kg, 0.15 mg/kg, or (b) 0.075 mg/kg of artesunate (AS) are shown. We infected mice with the Uganda Palo Alto Marburg (FUP/CB or PAM) progenitor strain before it was subjected to any drug pressure. Arrows indicate day of intravenous drug delivery. In panel a, day 0 represents the fourth day post-inoculation of mice. Results were reproducible in several mice treated at each dose