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Table 4 Tumor characteristics reported in the literature or calculated by extrapolation

From: Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection

Tumor diameter, mm Tumor weight, mg Tumor volume, mL (cm3) Number of cancer cells Percentage fraction of mutant ctDNA Number of cancer genomes per 10 mL of blood Chance of progressionc Mammographic screen sensitivityd
27 10,000 10a 10,000,000,000 1:1000 6   
12.5 1000 1b 1,000,000,000 1:10,000 0.6   
10 500 0.5 500,000,000 1:20,000 0.3 50% 91%
8 250 0.25 250,000,000 1:40,000 0.15 25%  
6 125 0.12 125,000,000 1:80,000 < 0.1   
5 62 0.06 62,000,000 1:160,000 < 0.1 6% 26%
4 31 0.03 32,000,000 1:320,000 < 0.1   
3 16 0.015 16,000,000 1:640,000 < 0.1   
2.4 8 0.007 8,000,000 1:1,300,000 < 0.1   
2 4 0.0035 4,000,000 1:2,600,000 < 0.1   
1.5 2 0.0017 2,000,000 1:5,200,000 < 0.1   
1.1 1 0.0008 1,000,000 1:10,000,000 < 0.1 0.05%  
  1. aAs reported by Abbosh et al. [21]
  2. bAs reported by Del Monte [43]
  3. cAs reported by Cohen et al. [64]
  4. dAs reported by Erdi [67]