Table 4 Tumor characteristics reported in the literature or calculated by extrapolation
From: Utility of circulating tumor DNA in cancer diagnostics with emphasis on early detection
Tumor diameter, mm | Tumor weight, mg | Tumor volume, mL (cm3) | Number of cancer cells | Percentage fraction of mutant ctDNA | Number of cancer genomes per 10Â mL of blood | Chance of progressionc | Mammographic screen sensitivityd |
|---|---|---|---|---|---|---|---|
27 | 10,000 | 10a | 10,000,000,000 | 1:1000 | 6 | Â | Â |
12.5 | 1000 | 1b | 1,000,000,000 | 1:10,000 | 0.6 | Â | Â |
10 | 500 | 0.5 | 500,000,000 | 1:20,000 | 0.3 | 50% | 91% |
8 | 250 | 0.25 | 250,000,000 | 1:40,000 | 0.15 | 25% | Â |
6 | 125 | 0.12 | 125,000,000 | 1:80,000 | < 0.1 |  |  |
5 | 62 | 0.06 | 62,000,000 | 1:160,000 | < 0.1 | 6% | 26% |
4 | 31 | 0.03 | 32,000,000 | 1:320,000 | < 0.1 |  |  |
3 | 16 | 0.015 | 16,000,000 | 1:640,000 | < 0.1 |  |  |
2.4 | 8 | 0.007 | 8,000,000 | 1:1,300,000 | < 0.1 |  |  |
2 | 4 | 0.0035 | 4,000,000 | 1:2,600,000 | < 0.1 |  |  |
1.5 | 2 | 0.0017 | 2,000,000 | 1:5,200,000 | < 0.1 |  |  |
1.1 | 1 | 0.0008 | 1,000,000 | 1:10,000,000 | < 0.1 | 0.05% |  |