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Table 1 Baseline characteristics stratified by gender and treatment group. Baseline characteristics of patients in the per-protocol population. Numbers are N (%) unless otherwise stated

From: Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study

Characteristics

Control group (N = 510)

Isoniazid group (N = 514)

Ethambutol group (N = 524)

All patients (N = 1548)

Sex

Male (N = 356)

Female (N = 154)

Male (N = 351)

Female (N = 163)

Male (N = 369)

Female (N = 155)

Male (N = 1076)

Female (N = 472)

Age group*

 ≤ 30 years

155 (44)

89 (58)

170 (48)

84 (52)

161 (44)

80 (52)

486 (45)

253 (54)

 > 30 years

201 (56)

65 (42)

181 (52)

79 (48)

208 (56)

75 (48)

590 (55)

219 (46)

Weight group*

 < 40 kg

14 (4)

36 (23)

14 (4)

30 (18)

29 (8)

29 (19)

57 (5)

95 (20)

 40–45 kg

45 (13)

35 (23)

54 (15)

36 (22)

54 (15)

28 (18)

153 (14)

99 (21)

 > 45–55 kg

163 (46)

43 (28)

159 (45)

51 (31)

149 (40)

55 (35)

471 (44)

149 (32)

 > 55 kg

134 (38)

40 (26)

124 (35)

46 (28)

137 (37)

43 (28)

395 (37)

129 (27)

BMI

 < 18.5

196 (55)

71 (46)

199 (57)

73 (45)

211 (57)

64 (41)

606 (56)

208 (44)

 ≥ 18.5

160 (45)

83 (54)

152 (43)

90 (55)

158 (43)

91 (59)

470 (44)

264 (56)

Race or ethnic group*

 Black

171 (48)

67 (44)

150 (43)

60 (37)

173 (47)

64 (41)

494 (46)

191 (40)

 Asian

109 (31)

51 (33)

107 (30)

47 (29)

119 (32)

42 (27)

335 (31)

140 (30)

 Mixed race or other

76 (21)

36 (23)

94 (27)

56 (34)

77 (21)

49 (32)

247 (23)

141 (30)

Smoking status*

 Never

133 (37)

113 (73)

121 (34)

110 (67)

127 (34)

103 (66)

381 (35)

326 (69)

 Past

105 (29)

14 (9)

100 (28)

11 (7)

117 (32)

17 (11)

322 (30)

42 (9)

 Current

118 (33)

27 (18)

130 (37)

42 (26)

125 (34)

35 (23)

373 (35)

104 (22)

HIV positivity*

21 (6)

17 (11)

23 (7)

14 (9)

17 (5)

18 (12)

61 (6)

49 (10)

Cavitation*ǁ

268 (75)

100 (65)

244 (70)

113 (69)

264 (72)

103 (66)

776 (72)

316 (67)

Area of lung involvement (%, (SD))

21.5 (12.5)

20.1 (12.4)

20.9 (13.1)

19.2 (12.1)

20.9 (12.2)

19.7 (11.0)

21.1 (12.6)

19.7 (11.9)

Smear grading

 Neg

14 (4)

7 (5)

14 (4)

5 (3)

17 (5)

7 (5)

45 (4)

19 (4)

 1+

32 (9)

15 (10)

24 (7)

17 (10)

25 (7)

14 (9)

81 (8)

46 (10)

 2+

43 (12)

19 (12)

52 (15)

26 (16)

62 (17)

22 (14)

157 (15)

67 (14)

 3+

86 (24)

42 (27)

79 (23)

37 (23)

82 (22)

32 (21)

247 (23)

111 (24)

 4+

181 (51)

71 (46)

182 (52)

78 (48)

183 (50)

80 (52)

546 (51)

229 (49)

LJ

 Positive

283 (79)

117 (76)

277 (79)

137 (84)

294 (80)

132 (85)

854 (81)

386 (82)

 Negative

33 (9)

14 (9)

25 (7)

12 (7)

31 (8)

4 (3)

89 (8)

30 (6)

 Contaminated

29 (8)

16 (10)

38 (11)

14 (9)

33 (9)

16 (10)

100 (9)

46 (10)

 Indeterminate

11 (3)

7 (5)

11 (3)

0 (0)

11 (3)

3 (2)

33 (3)

10 (2)

 TTD (median [IQR])

14 [14–21]

14 [14–21]

14 [14–25]

14 [14–21]

21 [14–28]

14 [14–21]

14 [14–21]

14 [14–21]

MGIT

 Positive

329 (92)

141 (92)

319 (93)

157 (96)

332 (90)

147 (95)

980 (93)

445 (94)

 Negative

5 (1)

2 (1)

4 (1)

0 (0)

7 (2)

2 (1)

16 (2)

4 (1)

 Contaminated

11 (3)

4 (3)

10 (3)

6 (4)

15 (4)

3 (2)

36 (3)

13 (3)

 False positive

2 (1)

0 (0)

5 (1)

0 (0)

4 (1)

0 (0)

11 (1)

0 (0)

 Indeterminate

9 (3)

7 (5)

13 (4)

0 (0)

11 (3)

3 (2)

13 (1)

10 (2)

 TTP (median [IQR])

4.81 [3.71–6.66]

5.13 [3.79–6.79]

4.92 [3.70–6.39]

5.04 [4.03–6.43]

4.83 [3.67–6.58]

4.73 [3.70–6.50]

4.83 [3.71–6.50]

5.04 [3.88–6.46]

  1. p values for categorical variables are calculated using chi-squared test and for the continuous variable using Mann-Whitney U test
  2. HIV human immunodeficiency virus, TTD time to detect a positive culture in days on LJ media, TTP time to detect a positive culture in days in MGIT, IQR interquartile range
  3. *Males and females were significantly different at baseline for weight, age, race, smoking, HIV, cavitation, area of lung involvement and LJ TTD; p values were ≤ 0.001, 0.002, 0.013, ≤ 0.001, 0.001, 0.022, 0.05 and 0.04 respectively
  4. Race or ethnic group was reported by the investigator. Asian category included both South Asians and East Asians. Mixed race or other included mixed race, coloured and Caucasian
  5. ǁCavitation status was missing for 148 patients