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Table 5 Univariate and multivariable analysis of risk factors associated with clinical malaria infections

From: A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting—high coverage and safety, but no significant impact on transmission

 

Intervention shehias

Control shehias

Survey population (n; %)1

Malaria cases (n; %)2

OR (CI95%)

aOR3(CI95%)

p value

Survey population

(n; %)1

Malaria cases (n; %)2

OR (CI95%)

aOR3 (CI95%)

p value

Residing in households sprayed in the last 12 months

 No

1316; 12.5

18; 23.4

1 (Ref)

1 (Ref)

1437; 12.3

24; 18.1

1 (Ref)

1 (Ref)

 Yes

9218; 87.5

59; 76.6

0.4; 0.3–0.7

0.5; 0.2–0.9

0.018

10,205; 87.7

109; 82.0

0.6; 0.4–0.9

0.6; 0.4–1.0

0.074

Residing in household with at least one mosquito net

 No

1283; 12.2

9; 11.7

1 (Ref)

1 (Ref)

1739; 14.9

16; 12.0

1 (Ref)

1 (Ref)

 Yes

9251; 87.8

68; 88.3

1.0; 0.5–2.0

2.8; 0.9–9.1

0.085

9903; 85.1

117; 88.0

1.3; 0.8–2.2

2.6; 1.2–5.5

0.015

Residing in households with at least one mosquito net and/or sprayed in the past 12 months

 No

293; 2.8

6; 7.8

1 (Ref)

1 (Ref)

200; 1.7

3; 2.3

1 (Ref)

1 (Ref)

 Yes

10,241; 97.2

71; 92.2

0.3; 0.1–0.7

0.4; 0.1–1.9

0.262

11,442; 98.3

130; 97.7

0.7; 0.2–2.0

0.5; 0.1–2.1

0.356

Age

 < 5 years

1622; 15.4

4; 5.2

1 (Ref)

1 (Ref)

1785; 15.3

10; 7.5

1 (Ref)

1 (Ref)

 5–14 years

2725; 25.9

22; 28.6

3.3; 1.1–9.4

3.7; 1.2–11.1

0.019

3104; 26.7

30; 22.6

1.7; 0.8–3.6

2.1; 1.0–4.4

0.064

 15–24 years

1895; 18.0

27; 35.1

5.7; 2.0–16.4

4.4; 1.5–13.1

0.009

2034; 17.5

42; 31.6

3.8; 1.8–7.7

3.7; 1.7–8.0

0.001

 > 25 years

4292; 40.7

24; 31.2

2.2; 0.8–6.4

1.4; 0.5–4.3

0.510

4719; 40.5

51; 38.4

1.9; 1.0–3.8

1.6; 0.8–3.2

0.228

Sex

 Female

5440; 51.6

26; 33.8

1 (Ref)

1 (Ref)

6028; 51.8

50; 37.6

1 (Ref)

1 (Ref)

 Male

5094; 48.4

51; 66.2

2.1; 1.3–3.4

2.0; 1.2–3.2

0.009

5614; 48.2

83; 62.4

1.8; 1.3–2.6

1.7; 1.1–2.5

0.009

Travel in last month

 No travel

10,152; 96.4

54; 70.1

1 (Ref)

1 (Ref)

11,262; 96.7

95; 71.4

1 (Ref)

1 (Ref)

 Within Zanzibar

336; 3.2

3; 3.9

1.7; 0.5–5.3

2.3; 0.7–7.6

0.160

325; 2.8

3; 2.3

1.1; 0.3–3.4

1.1; 0.3–3.7

0.838

 Outside of Zanzibar

43; 0.4

20; 26.0

87.5; 46.4–165.1

103.4; 49.8–214.9

< 0.001

55; 0.5

35; 26.3

75.8; 42.3–136.0

85.0; 4.2–159.8

< 0.001

Reported use of a mosquito net the previous night

 No

2606; 24.7

29; 37.7

1 (Ref)

1 (Ref)

3430; 29.5

45; 33.8

1 (Ref)

1 (Ref)

 Yes

7928; 75.3

48; 62.3

0.5; 0.3–0.8

0.5; 0.3–1.0

0.033

8212; 70.5

88; 66.2

0.8; 0.6–1.2

0.7; 0.5–1.1

0.167

  1. 1Healthy individuals at study baseline: N(Intervention shehias) = 10,534; N(Control shehias) = 11,642; 194 (0.9%) individuals excluded due to missing data, and 126 (0.6%) excluded for being positive for malaria by PCR
  2. 2Malaria cases diagnosed at health facilities during the study period May 2016–August 2017: N(Intervention shehias) = 77; N(Control shehias) = 133; 141 (40.2%) individuals excluded due to missing data
  3. 3All variables were included in the model of adjusted OR; significant p values are presented in italics