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Table 2 Weight at the three assessment times in fresh and frozen cycle ART-conceived singleton babies: association with ART treatment parameters

From: The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study

 

Adjusted BW (GROW)

N = 5071

Weight at 6/8 weeks

N = 3908

Weight at school entry

N = 2571

Effect size (95% CI) (g)

P

Effect size (95% CI) (g)

P

Effect size (95% CI) (g)

P

Fresh embryo-transfer cycle

Reference

< 0.001

Reference

< 0.001

Reference

0.172

Frozen embryo-transfer cycle

127.4 (95.0, 162.8)

133.3 (75.4, 190.2)

257.8 (-115.5, 650.7)

Scottish Deprivation Index Quintile

 1 (most deprived)

-60.8 (-111.1, -12.0)

0.218

23.9 (-53.4, 101.9)

0.288

494.1 (-63.4, 1051)

0.502

 2

-24.0 (-67.6, 16.4)

53.0 (-12.8, 118.3)

67.7 (-328.9, 464.3)

 3

-11.1 (-50.5, 30.0)

29.8 (-29.8, 92.7)

69.3 (-295.1, 431.7)

 4

-14.8 (-51.0, 18.0)

-16.4 (-74.6, 40.0)

22.2 (-321.9, 323.1)

 5 (least deprived)

Reference

Reference

Reference

Smoked during pregnancy

-181.5 (-230.6, -133.5)

< 0.001

-117.9 (-197.4, -39.5)

0.004

118.6 (-354.0, 667.8)

0.649

Maternal age (linear)

9.8 (-30.2, 52.3)

0.234

-69.9 (-172.4, 41.2)

0.225

205.9 (-440.8, 840.6)

0.818

Maternal age (quadratic)

53.6 (-6.4, 114.4)

14.0 (-90.6, 110.7)

-157.0 (-800.4, 448.9)

Paternal age (linear)

4.6 (-26.3, 33.3)

0.681

-32.6 (-80.1, 17.0)

0.423

-19.0 (-306.9, 280.7)

0.750

Paternal age (quadratic)

-11.7 (-38.1, 14.8)

11.2 (-35.3, 58.0)

122.9 (-192.7, 504.1)

ICSI

-8.5 (-47.6, 31.8)

0.674

27.4 (-27.3, 84.3)

0.347

124.8 (-270.9, 551.2)

0.543

No. previous ART cycles

 0

Reference

0.875

Reference

0.764

Reference

0.598

 1

5.1 (-31.0, 39.5)

23.6 (-35.6, 77.6)

195.3 (-149.9, 537.8)

 2

-7.0 (-48.0, 36.3)

-7.4 (-76.1, 61.3)

-18.4 (-427.5, 390.0)

 3 or more

11.0 (-29.6, 50.5)

-5.7 (-75.7, 61.2)

-44.9 (-461.8, 342.2)

Infertility cause

 Fallopian tubal damage

-14.0 (-58.4, 34.4)

0.555

-34.2 (-112.6, 40.1)

0.370

-210.3 (-610.3, 229.3)

0.344

 Endometrial

-18.4 (-65.2, 35.5)

0.482

-71.0 (-148.0, 13.1)

0.074

-470.8 (-915.2, -33.0)

0.042

 Ovulatory disorders

-22.1 (-77.1, 33.0)

0.426

-37.8 (-125.7, 50.2)

0.409

-88.8 (-604.9, 408.4)

0.725

 Male-factor cause

-13.5 (-52.9, 28.4)

0.527

-28.1 (-90.4, 32.4)

0.364

-12.1 (-375.0, 352.7)

0.949

 Idiopathic

-42.8 (-87.3, 5.9)

0.070

-44.2 (-114.6, 35.7)

0.229

-272.0 (-673.0, 173.5)

0.206

  1. Results from multiple linear regression models for weight at the three time points, adjusting for type of ART conception, Scottish Index of Multiple Deprivation, maternal age and smoking status during pregnancy, paternal age, whether or not ICSI was used, the number of previous ART cycles and causes of infertility. Full model details are available in Additional file 1: Table S4
  2. Quoted effect sizes represent the difference from the indicated reference category. The effect size for maternal smoking represents the difference between mothers who smoked and those who did not smoke during pregnancy. The effect size for ICSI represents the difference between ART cycles in which ICSI was used and those in which it was not. The effect size for infertility causes represents the difference between the stated cause being identified within the couple and not being identified
  3. P values are calculated from an omnibus chi-squared test that parameter estimates are simultaneously zero
  4. Note that for ease of interpretation, the effect sizes for the linear and quadratic components of maternal/paternal age represent the change in outcome for a 10-year change in maternal/paternal age
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BMC Medicine

ISSN: 1741-7015

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