TY - JOUR AU - Amaratunga, Chanaki AU - Andrianaranjaka, Voahangy Hanitriniaina AU - Ashley, Elizabeth AU - Bethell, Delia AU - Björkman, Anders AU - Bonnington, Craig A. AU - Cooper, Roland A. AU - Dhorda, Mehul AU - Dondorp, Arjen AU - Erhart, Annette AU - Fairhurst, Rick M. AU - Faiz, Abul AU - Fanello, Caterina AU - Fukuda, Mark M. AU - Guérin, Philippe AU - van Huijsduijnen, Rob Hooft AU - Hien, Tran Tinh AU - Hong, N. V. AU - Htut, Ye AU - Huang, Fang AU - Humphreys, Georgina AU - Imwong, Mallika AU - Kennon, Kalynn AU - Lim, Pharath AU - Lin, Khin AU - Lon, Chanthap AU - Mårtensson, Andreas AU - Mayxay, Mayfong AU - Mokuolu, Olugbenga AU - Morris, Ulrika AU - Ngasala, Billy E. AU - Amambua-Ngwa, Alfred AU - Noedl, Harald AU - Nosten, François AU - Onyamboko, Marie AU - Phyo, Aung Pyae AU - Plowe, Christopher V. AU - Pukrittayakamee, Sasithon AU - Randrianarivelojosia, Milijaona AU - Rosenthal, Philip J. AU - Saunders, David L. AU - Sibley, Carol Hopkins AU - Smithuis, Frank AU - Spring, Michele D. AU - Sondo, Paul AU - Sreng, Sokunthea AU - Starzengruber, Peter AU - Stepniewska, Kasia AU - Suon, Seila AU - Takala-Harrison, Shannon AU - Thriemer, Kamala AU - Thuy-Nhien, Nguyen AU - Tun, Kyaw Myo AU - White, Nicholas J. AU - Woodrow, Charles AU - WWARN K13 Genotype-Phenotype Study Group PY - 2019 DA - 2019/01/17 TI - Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis JO - BMC Medicine SP - 1 VL - 17 IS - 1 AB - Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular marker of the slow clearance phenotype has been identified: single genetic changes within the propeller region of the Kelch13 protein (pfk13; Pf3D7_1343700). Global searches have identified almost 200 different non-synonymous mutant pfk13 genotypes. Most mutations occur at low prevalence and have uncertain functional significance. To characterize the impact of different pfk13 mutations on parasite clearance, we conducted an individual patient data meta-analysis of the associations between parasite clearance half-life (PC1/2) and pfk13 genotype based on a large set of individual patient records from Asia and Africa. SN - 1741-7015 UR - https://doi.org/10.1186/s12916-018-1207-3 DO - 10.1186/s12916-018-1207-3 ID - Amaratunga2019 ER -