Skip to main content

Table 1 Summary of genotyping results by study site. Samples with mixed genotyping are excluded. Details of mutations are listed in Additional file 2: Table S2A (codons 1–440) and S2B (codons 441–726), and mixed genotypes are listed in Additional file 2: Table S3. Results are sorted by continent, country, site, and year of study

From: Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatmentsa WWARN individual patient data meta-analysis

Study ID Country Site ID Site Year Total N isolates Non-synonymous changes between
Codon 1–440 Codon 441–726
N N % [95% CI]
Asia
 7 Bangladesh 1 Bandarban 2004–2005 21 2 0 0 [0–15]
 16 Bangladesh 2 Ramu 2012 55 4 0 0 [0–7]
 9 Cambodia 3 Anlong Veng 2012–2014 107 ND 103 96 [91–99]
 2 Cambodia 4 Tasanh 2008–2009 46 ND 38 83 [69–91]
 6 Cambodia 5 Pailin 2008–2009 36 ND 34 94 [82–98]
 16 Cambodia 5 Pailin 2011–2012 87 0 80 92 [84–96]
 10 Cambodia 6 Preah Vihear 2012–2013 65 ND 22 34 [24–46]
 11 Cambodia 6 Preah Vihear 2011–2012 110 0 22 20 [14–28]
 10 Cambodia 7 Pursat 2012–2013 107 ND 82 77 [68–84]
 16 Cambodia 7 Pursat 2011–2012 104 0 77 74 [65–82]
 10 Cambodia 8 Ratanakiri 2012–2013 66 ND 7 11 [5–20]
 16 Cambodia 8 Ratanakiri 2011–2012 119 0 4 3 [1–8]
 11 China 9 Tengchong 2012 12 ND 10 83 [55–95]
 11 China 10 Yingjiang 2009–2012 110 ND 61 55 [46–64]
 12 LPDR 11 Attapeu 2013–2014 18 0 4 22 [9–45]
 14 LPDR 11 Attapeu 2011–2012 118 0 2 2 [0–6]
 3 LPDR 12 Savannakhet 2010 33 0 0 0 [0–10]
 15 Myanmar 13 Hpa Pun 2013 32 1 14 44 [28–61]
 12 Myanmar 14 Myitkyina 2013–2014 43 0 21 49 [35–63]
 13 Myanmar 15 Pyin Oo Lwin 2012–2014 31 0 15 48 [32–65]
 16 Myanmar 16 Shwe Kyin 2011–2013 74 17 20 27 [18–38]
 12 Myanmar 17 Thabeikkyin 2013–2014 71 1 12 17 [10–27]
 16 Thailand 18 Ranong 2011–2012 19 0 13 68 [46–85]
 16 Thailand 19 Srisaket 2011–2013 34 0 30 88 [73–95]
 4 Thailand 20 TW border 2001 9 0 0 0 [0–30]
 4 Thailand 20 TW border 2002 58 0 0 0 [0–6]
 4 Thailand 20 TW border 2003 33 3 0 0 [0–10]
 4 Thailand 20 TW border 2004–2006 28 0 0 0 [0–12]
 4 Thailand 20 TW border 2007 26 2 1 4 [1–19]
 4 Thailand 20 TW border 2008 341 30 57 17 [13–21]
 1 Thailand 20 TW border 2008 5 1 1 20 [4–62]
 4 Thailand 20 TW border 2009 227 38 47 21 [16–26]
 4 Thailand 20 TW border 2010 138 20 46 33 [26–42]
 4 Thailand 20 TW border 2011 113 17 66 58 [49–67]
 16 Thailand 20 TW border 2011–2012 94 5 61 65 [55–74]
 4 Thailand 20 TW border 2012 116 14 80 69 [60–77]
 4 Thailand 20 TW border 2013 80 1 67 84 [74–90]
 4 Thailand 20 TW border 2014 23 0 21 91 [73–98]
 16 Viet Nam 21 Binh Phuoc 2011–2012 103 0 28 27 [20–36]
 5 Viet Nam 22 Phuoc Long 2010–2011 92 0 34 37 [28–47]
 8 Viet Nam 23 Tra Lang 2012 83 ND 67 81 [71–88]
Africa
 16 DRC 24 Kinshasa 2013 117 32 3 3 [1–7]
 18 Madagascar 25 Ankazobe 2014 5 ND 0 0 [0–43]
 18 Madagascar 26 Brickaville 2014 44 ND 4 9 [4–21]
 16 Nigeria 27 Ilorin 2011–2012 36 14 0 0 [0–10]
 17 Tanzania 28 Fukayosi 2012 41 ND 0 0 [0–10]
  1. DRC Democratic Republic of Congo, LPDR Lao People’s Democratic Republic, TW border Thai Western border, ND not done
\