Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

Table 4 Comparison of PC_{1/2 for} pfk13 NS mutations between study sites in Asia. Only mutations with isolates available from at least five patients from at least two sites are shown

Mutant codon	N sites	N patients	p value for comparison by site
Mutant codon	N sites	N patients	Univariable	Multivariable¹
K189T	3	8	0.324	0.278
E252Q	2	114	< 0.001	< 0.001
K438N	2	10	0.007	0.322
P441L	3	53	0.991	0.908
F446I	7	79	0.002	0.005
G449A	3	6	0.013	No data²
N458Y	2	34	0.583	0.249
M476I	3	8	< 0.001	0.014
A481V	2	5	0.664	No data²
Y493H	7	33	0.050	0.029
R515K	2	8	0.525	No data²
G538V	2	24	0.599	No data²
R539T	9	76	0.623	0.766
I543T	4	77	0.084	0.821
P553L	4	16	0.654	0.228
R561H	4	36	0.219	0.183
V568G	2	5	0.563	No data²
P574L	7	38	0.001	0.003
C580Y	13	450	< 0.001	< 0.001

¹Adjusted for total artemisinin derivative dose in the first 3 days, partner drug, initial parasitemia and patient age
²Could not fit multivariable model due to small number of observations, overall or within sites

ISSN: 1741-7015