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Table 4 Comparison of PC1/2 for pfk13 NS mutations between study sites in Asia. Only mutations with isolates available from at least five patients from at least two sites are shown

From: Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatmentsa WWARN individual patient data meta-analysis

Mutant codon N sites N patients p value for comparison by site
Univariable Multivariable1
K189T 3 8 0.324 0.278
E252Q 2 114 < 0.001 < 0.001
K438N 2 10 0.007 0.322
P441L 3 53 0.991 0.908
F446I 7 79 0.002 0.005
G449A 3 6 0.013 No data2
N458Y 2 34 0.583 0.249
M476I 3 8 < 0.001 0.014
A481V 2 5 0.664 No data2
Y493H 7 33 0.050 0.029
R515K 2 8 0.525 No data2
G538V 2 24 0.599 No data2
R539T 9 76 0.623 0.766
I543T 4 77 0.084 0.821
P553L 4 16 0.654 0.228
R561H 4 36 0.219 0.183
V568G 2 5 0.563 No data2
P574L 7 38 0.001 0.003
C580Y 13 450 < 0.001 < 0.001
  1. 1Adjusted for total artemisinin derivative dose in the first 3 days, partner drug, initial parasitemia and patient age
  2. 2Could not fit multivariable model due to small number of observations, overall or within sites
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