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Table 5 Summary of PC1/2 by mutant codon and region showing proportion of isolates from a study site with PC1/2 > 5.5 h and proportion of Day 3 positive isolates. Mutant codons represented by fewer than 5 isolates are indicated in bold

From: Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatmentsa WWARN individual patient data meta-analysis

  N Patients with PC1/2 > 5.5 h (%) PC1/2 Percentiles (hours) Patients positive on day 3 (%)
Median 25 75 5 95 Min Max
Asia
 WT 1440 5 2.7 2.1 3.4 1.4 5.3 0.7 12.4 9
G112E 1 0 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0
 K189 T 8 0 2.8 2.1 4.0 1.3 4.3 1.3 4.3 0
I205T 1 100 6.8 6.8 6.8 6.8 6.8 6.8 6.8 100
R223K 1 0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 0
R239Q 3 0 4.6 3.7 5.2 3.7 5.2 3.7 5.2 67
 E252Q 114 11 4.4 3.8 5.0 2.8 6.6 2.0 7.4 46
D281V 3 0 3.7 2.9 5.4 2.9 5.4 2.9 5.4 33
 K438 N 10 0 2.4 2.2 2.9 1.4 3.7 1.4 3.7 30
 P441L 53 75 6.4 5.6 7.4 3.5 8.9 2.0 9.4 77
P443S 1 100 6.6 6.6 6.6 6.6 6.6 6.6 6.6 100
 F446I 79 47 5.4 4.0 6.5 2.3 8.6 1.6 10.0 32
 G449A 6 67 6.6 4.5 7.1 2.3 9.5 2.3 9.5 67
 N458Y 34 88 7.5 6.1 8.4 5.0 9.8 5.6 10.1 91
C469Y 1 100 6.2 6.2 6.2 6.2 6.2 6.2 6.2 100
 M476I 8 63 6.1 4.2 7.1 3.5 7.9 3.5 7.9 71
K479I 4 75 6.4 5.8 6.8 5.4 7.0 5.4 7.0 100
 A481V 5 40 4.9 4.7 6.0 2.7 7.6 2.7 7.6 40
S485N 2 50 4.7 3.7 5.8 3.7 5.8 3.7 5.8 50
L492S 1 0 4.3 4.3 4.3 4.3 4.3 4.3 4.3 0
 Y493H 33 82 7.4 6.7 8.0 4.3 9.0 4.3 9.1 84
 R515K 5 40 5.3 5.3 6.6 3.5 7.1 3.5 7.1 80
N525D 1 0 4.7 4.7 4.7 4.7 4.7 4.7 4.7 0
 P527H/L* 21 29 4.8 4.2 5.6 3.4 6.0 3.3 6.3 67
G533A 4 50 5.6 5.2 6.3 5.0 6.9 5.0 6.9 100
 N537I 8 13 5.1 4.5 5.4 3.9 6.3 3.9 6.3 63
 G538 V 24 46 5.2 4.4 6.1 4.2 7.2 3.1 7.7 48
 R539T 76 61 5.8 5.0 6.8 3.3 9.3 3.1 10.9 56
 I543T 77 70 6.4 4.7 7.7 3.0 9.2 2.6 11.3 52
 P553L 16 69 6.1 4.7 6.8 3.0 10.1 3.0 10.1 63
 R561H 36 97 7.2 6.1 7.7 5.5 9.1 5.0 9.2 92
 V568G 5 100 6.5 5.9 7.0 5.7 7.9 5.7 7.9 100
 P574L 38 61 5.9 4.9 7.2 3.6 9.6 2.3 9.8 47
R575K 2 100 8.1 7.3 8.8 7.3 8.8 7.3 8.8 100
 C580Y 450 74 6.6 5.5 7.6 4.1 9.3 2.3 13.9 75
D584V 1 0 5.4 5.4 5.4 5.4 5.4 5.4 5.4 100
F614L 2 0 3.3 2.5 4.1 2.5 4.1 2.5 4.1 50
 P667T** 5 80 6.7 6.5 7.0 5.3 8.7 5.3 8.7 100
 A675V 49 76 6.7 5.5 7.3 3.4 8.4 1.4 8.8 80
A676D 1 0 3.4 3.4 3.4 3.4 3.4 3.4 3.4 0
H719N 2 50 5.6 5.5 5.8 5.5 5.8 5.5 5.8 50
Africa
 WT 159 1 2.2 1.7 2.8 1.2 4.0 0.7 6.3 1
 N87K 1 0 2.4 2.4 2.4 2.4 2.4 2.4 2.4 0
 L143P 1 0 2.7 2.7 2.7 2.7 2.7 2.7 2.7 0
 T149S 2 0 1.7 1.2 2.2 1.2 2.2 1.2 2.2 0
 A175T 1 0 1.7 1.7 1.7 1.7 1.7 1.7 1.7 0
 K189 T/N 33 3 2.1 1.7 2.5 0.9 4.6 0.8 7.1 0
 R255K 3 0 2.0 0.8 2.2 0.8 2.2 0.8 2.2 0
 S522C 1 0 2.4 2.4 2.4 2.4 2.4 2.4 2.4 0
 A578S 2 0 1.8 1.1 2.6 1.1 2.6 1.1 2.6 0
 Q613E 1 0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 0
  1. *20 P527H, one P527L, analyzed together; two P527H not analyzed since clearance data did not meet criteria
  2. **5 P667T; one P667T not analyzed since clearance data did not meet criteria
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