| |
Hazard ratio (univariate)
|
p-value
|
Hazard ratio (multivariate)
|
p-value
|
|---|
|
Age
|
|
68–79
|
4.63
|
2.24×10−04
|
2.09
|
1.45×10−01
|
|
> 79
|
12.86
|
8.90×10−11
|
3.87
|
8.33×10−03
|
|
Male sex
|
0.64
|
1.35×10−02
|
0.96
|
8.72×10−01
|
|
Hypertension
|
1.34
|
1.47×10−01
|
0.53
|
1.98×10−02
|
|
Dyslipidemia
|
0.55
|
7.16×10−03
|
0.38
|
7.91×10−03
|
|
Smoking habits
|
|
Yes
|
0.43
|
1.67×10−03
|
1.25
|
5.04×10−01
|
|
Ex-smokers
|
1.13
|
7.95×10−01
|
4.14×10-08
|
9.95×10−01
|
|
CAD
|
0.41
|
2.00×10−03
|
0.99
|
9.86×10−01
|
|
Previous CABG
|
1.16
|
7.10×10−01
|
1.92
|
2.61×10−01
|
|
Previous PCI
|
1.28
|
2.69×10−01
|
1.66
|
9.64×10−02
|
|
Heart failure
|
3.67
|
1.07×10−07
|
1.81
|
8.98×10−02
|
|
Atrial fibrillation
|
2.37
|
7.03×10−04
|
1.30
|
4.52×10−01
|
|
Cerebrovascular disease
|
3.17
|
4.10×10−07
|
1.96
|
2.67×10−02
|
|
Diabetes
|
1.99
|
1.83×10−04
|
1.05
|
8.58×10−01
|
|
Creatinine (>1.2 mg/dL)
|
2.89
|
8.70×10−09
|
1.29
|
3.37×10−01
|
|
Killip class
|
|
II
|
3.43
|
4.89×10−09
|
1.77
|
4.26×10−02
|
|
III
|
4.87
|
9.12×10−10
|
3.31
|
4.76×10−04
|
|
ACS classification
|
|
STEMI
|
0.49
|
1.34×10−03
|
0.72
|
3.00×10−01
|
|
NOESY RF risk score
|
|
≥ 0.454
|
6.45
|
2.16×10−16
|
3.71
|
2.36×10−05
|
|
GRACE score#
|
|
≥ 170
|
6.05
|
3.76×10−06
|
–
|
–
|
|
NOESY RF + GRACE#
|
|
≥ 7.7
|
9.33
|
2.16×10−16
|
–
|
–
|
- Correlation with the outcome for prognostic features and RF risk score in the full dataset, using univariate and multivariate analysis. Age split into tertiles. In the multivariate, hazard ratios of all the variable were included together in the analysis
- CAD coronary artery diseases, CABG coronary artery bypass grafting, PCI percutaneous coronary intervention, ACS acute coronary syndrome, STEMI ST-segment elevation myocardial infarction, NOESY nuclear Overhauser effect spectroscopy, RF random forest, GRACE Global Registry of Acute Coronary Events
- #These variables were not included in the multivariate analysis due to the strong co-linearity between GRACE score and the other clinical variables [66]
