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Table 1 Summary of characteristics of included studies

From: Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

Category Characteristics of participants in study Number of studies
Disease or condition AUD 38
Drug addiction or smoking ± AUD 18
Psychiatric disorders ± AUD 13
Impulse control disorders 9
Obesity or eating disorders 6
Inflammatory disorders 3
malignancies 2
Target dose of naltrexonea (mg) ≤4.5 5
16–49 7
50 61
100 12
>100 8
Mean age where givenb (years) 10 to <20 2
20 to <30 2
30 to <40 11
40 to <50 62
50 to <60 3
≥60 2
Length of studyc (weeks) 4–7 5
8–11 17
12–15 42
16–25 18
26–52 6
  1. AUD alcohol use disorder
  2. a3 studies were multi-arm dose-finding studies
  3. b82 studies
  4. c88 studies