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Table 2 Multilevel modelling of changes in score from baseline to 12 month follow-up for remote cognitive behavioural therapy (RCBT) intervention versus treatment as usual (TAU)

From: Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial

  RCBT TAU Comparison
N Mean change from baseline (95% CI) N Mean change from baseline (95% CI) Difference (95% CI) P-value
SHAI
 3 months 53 –6.08(–7.90 to –4.26) 48 –5.97(–7.97 to –3.97) –0.11(–2.82 to 2.60) 0.936
 6 months 56 –9.48(–11.20 to –7.75) 56 –6.67(–8.30 to –5.04) –2.81(–5.11 to –0.50) 0.017
 9 months 46 –9.58(–11.33 to –7.84) 50 –6.78(–8.43 to –5.12) –2.81(–5.11 to –0.50) 0.017
 12 months 47 –10.60(–12.31 to –8.89) 47 –7.79(–9.43 to –6.16) –2.81(–5.11 to –0.50) 0.017
GAD 7
 3 months 52 –3.69(–5.09 to –2.28) 48 –4.79(–6.17 to –3.41) 1.10(–0.84 to 3.05) 0.265
 6 months 53 –6.22(–7.62 to –4.82) 55 –3.83(–5.21 to –2.44) –2.39(–4.40 to –0.39) 0.020
 9 months 43 –5.37(–7.05 to –3.69) 48 –4.48(–5.97 to –2.99) –0.89(–3.00 to 1.23) 0.408
 12 months 45 –6.68(–8.14 to –5.21) 46 –3.92(–5.40 to –2.45) –2.75(–4.82 to –0.68) 0.009
PHQ9
 3 months 52 –3.24(–4.69 to –1.80) 47 –3.01(–4.38 to –1.64) –0.23(–2.15 to 1.68) 0.812
 6 months 53 –4.67(–6.02 to –3.33) 55 –3.11(–4.46 to –1.76) 1.56(–3.45 to 0.33) 0.105
 9 months 43 –4.41(–6.06 to –2.76) 48 –3.24(–4.78 to –1.69) –1.17(–3.18 to 0.83) 0.250
 12 months 45 –5.05(–6.37 to –3.72 45 –2.69(–4.06 to –1.31) –2.36(–4.22 to –0.50) 0.013
PHQ15
 3 months 52 –0.35(–1.58 to 0.88) 48 –1.68(–3.16 to –0.19) 1.33(–0.52 to 3.17) 0.157
 6 months 54 –2.95(–4.11 to –1.78) 55 –1.62(–2.90 to –0.34) –1.33(–3.09 to 0.42) 0.137
 9 months 45 –2.62(–4.19 to –1.04) 49 –2.20(–3.47 to –0.92) –0.42(–2.38 to 1.53) 0.669
 12 months 46 –3.33(–4.62 to –2.04) 47 –1.77(–2.99 to –0.55) –1.57(–3.37 to 0.24) 0.089
EQ5D–5L (VAS)
 3 months 52 8.74 (3.70 to 13.79) 47 2.80(–2.35 to 7.96) 5.94(–1.22 to 13.11) 0.103
 6 months 54 13.66 (8.97 to 18.34) 55 11.10 (6.32 to 15.89) 2.56(–4.03 to 9.14) 0.446
 9 months 45 10.24 (5.28 to 15.21) 49 2.92 (–2.06 to 7.90) 7.33(–0.02 to 14.67) 0.051
 12 months 46 13.80 (8.90 to 18.71) 47 4.25 (–0.87 to 9.37) 9.56 (2.73 to 16.39) 0.006
WSAS
 3 months 51 –4.45(–6.63 to –2.27) 48 –3.36(–5.61 to –1.10) –1.10(–4.07 to 1.87) 0.468
 6 months 53 –7.52(–9.85 to –5.19) 55 –4.89(–7.03 to –2.75) –2.63(–5.72 to 0.45) 0.094
 9 months 44 –7.31(–9.81 to –4.81) 56 –5.77(–8.15 to –3.39) –1.54(–4.99 to 1.90) 0.377
 12 months 45 –7.89(–10.22 to –5.56) 56 –5.40(–7.79 to –3.01) –2.49(–5.73 to 0.75) 0.131
  RCBT TAU Unadjusted difference in change
  N Mean (SD) n Mean (SD) Mean (95% CI) (P-value)
QALYsa at 12 months 31 0.66 (0.22) 25 0.59 (0.31) 0.07 (0.07 to 0.21) (0.332)
  1. aQALYs at 12 months is based on the complete dataset over the 12-month follow-ups