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Fig. 3 | BMC Medicine

Fig. 3

From: Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure

Fig. 3

Model-predicted antibody kinetics during follow-up in individuals with or without previous malaria exposure. a The geometric mean antigen-specific total IgG levels over time for malaria antigens and TTd in each exposure group relative to the collection of the first sample at time t = 0. Solid lines denote the previously exposed while dashed lines denote the previously malaria naïve. The antibody levels in arbitrary antibody units are directly comparable only within the antigen. The dotted line represents the assay lower limit of quantification. b Parameter estimates for the kinetics of the total IgG response to P. falciparum antigens and TTd. Dots denote the model parameter estimates and capped error bars the corresponding 95% CrI. The different parameters are indicated by colours: half-life of antibody molecules (red), half-life of short-lived ASCs (blue), half-life of long-lived ASCs (green), and the proportion of long-lived ASCs in previously naïve (magenta) and in the previously exposed (black). Individuals were not stratified by prior malaria exposure status when the model was fitted to data on the response to TTd. The estimated population-level parameters with corresponding variance parameters are also available in Additional file 2: Table S1

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