Fig. 5
The average breadth of the antibody response for total IgG and IgG subclasses over time. Each panel represents either total IgG or one of the IgG subclasses. Black, blue, red, green, and yellow denote the total IgG, IgG1, IgG2, IgG3, and IgG4 response, respectively. The solid line and dashed lines represent the temporal kinetics in the average antibody breadth in previously exposed and previously naïve individuals, respectively, relative to the collection of the first sample at time t = 0. Antibody breadth is the number of recombinant P. falciparum antigens to which the individual displays antibody reactivity above a threshold of seropositivity (defined as the mean + 3 SD of the reactivity of 20 malaria unexposed controls)